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Plasma brain-derive...
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease.
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- Gonzalez-Ortiz, Fernando, 1990 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Kirsebom, Bjørn-Eivind (author)
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Contador, José (author)
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Tanley, Jordan E (author)
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Selnes, Per (author)
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Gísladóttir, Berglind (author)
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Pålhaugen, Lene (author)
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Suhr Hemminghyth, Mathilde (author)
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Jarholm, Jonas (author)
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Skogseth, Ragnhild (author)
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Bråthen, Geir (author)
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Grøndtvedt, Gøril (author)
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Bjørnerud, Atle (author)
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Tecelao, Sandra (author)
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Waterloo, Knut (author)
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- Aarsland, Dag (author)
- Karolinska Institutet
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Fernández-Lebrero, Aida (author)
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García-Escobar, Greta (author)
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Navalpotro-Gómez, Irene (author)
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Turton, Michael (author)
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- Hesthamar, Agnes (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Kac, Przemyslaw R., 1995 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Nilsson, Johanna, 1993 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Luchsinger, Jose (author)
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Hayden, Kathleen M (author)
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Harrison, Peter (author)
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Puig-Pijoan, Albert (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Hughes, Timothy M (author)
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Suárez-Calvet, Marc (author)
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Fladby, Tormod (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Nature communications. - 2041-1723. ; 15:1
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https://doi.org/10.1...
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Abstract
Subject headings
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- Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer's disease (AD). In blood, phosphorylated tau (p-tau) associates with Aβ pathophysiology but an AD-type neurodegeneration biomarker has been lacking. In this multicenter study (n=1076), we show that brain-derived tau (BD-tau) in blood increases according to concomitant Aβ ("A") and neurodegeneration ("N") abnormalities (determined using cerebrospinal fluid biomarkers); We used blood-based A/N biomarkers to profile the participants in this study; individuals with blood-based p-tau+/BD-tau+ profiles had the fastest cognitive decline and atrophy rates, irrespective of the baseline cognitive status. Furthermore, BD-tau showed no or much weaker correlations with age, renal function, other comorbidities/risk factors and self-identified race/ethnicity, compared with other blood biomarkers. Here we show that blood-based BD-tau is a biomarker for identifying Aβ-positive individuals at risk of short-term cognitive decline and atrophy, with implications for clinical trials and implementation of anti-Aβ therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gonzalez-Ortiz, ...
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Kirsebom, Bjørn- ...
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Contador, José
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Tanley, Jordan E
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Selnes, Per
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Gísladóttir, Ber ...
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show more...
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Pålhaugen, Lene
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Suhr Hemminghyth ...
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Jarholm, Jonas
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Skogseth, Ragnhi ...
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Bråthen, Geir
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Grøndtvedt, Gøri ...
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Bjørnerud, Atle
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Tecelao, Sandra
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Waterloo, Knut
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Aarsland, Dag
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Fernández-Lebrer ...
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García-Escobar, ...
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Navalpotro-Gómez ...
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Turton, Michael
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Hesthamar, Agnes
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Kac, Przemyslaw ...
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Nilsson, Johanna ...
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Luchsinger, Jose
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Hayden, Kathleen ...
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Harrison, Peter
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Puig-Pijoan, Alb ...
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Zetterberg, Henr ...
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Hughes, Timothy ...
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Suárez-Calvet, M ...
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Karikari, Thomas
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Fladby, Tormod
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Blennow, Kaj, 19 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature communica ...
- By the university
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University of Gothenburg
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Karolinska Institutet