Large-scale plasma proteomics in the UK Biobank modestly improves prediction of major cardiovascular events in a population without previous cardiovascular disease

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Large-scale plasma proteomics in the UK Biobank modestly improves prediction of major cardiovascular events in a population without previous cardiovascular disease

Royer, Patrick (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Björnson, Elias, 1988 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Adiels, Martin, 1976 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Josefson, Rebecca (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Hagberg, Eva (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Gummesson, Anders, 1973 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Bergström, Göran, 1964 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

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2024
2024
English.
In: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. - 2047-4873 .- 2047-4881.

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

[ ' A i m s I m p r o v e d i d e n t i f i c a t i o n o f i n d i v i d u a l s a t h i g h r i s k o f d e v e l o p i n g c a r d i o v a s c u l a r d i s e a s e w o u l d e n a b l e t a r g e t e d i n t e r v e n t i o n s a n d p o t e n t i a l l y l e a d t o r e d u c t i o n s i n m o r t a l i t y a n d m o r b i d i t y . O u r a i m w a s t o d e t e r m i n e w h e t h e r u s e o f l a r g e - s c a l e p r o t e o m i c s i m p r o v e s p r e d i c t i o n o f c a r d i o v a s c u l a r e v e n t s b e y o n d t r a d i t i o n a l r i s k f a c t o r s ( T R F s ) . M e t h o d s a n d r e s u l t s U s i n g p r o x i m i t y e x t e n s i o n a s s a y s , 2 9 1 9 p l a s m a p r o t e i n s w e r e m e a s u r e d i n 3 8 3 8 0 p a r t i c i p a n t s o f t h e U K B i o b a n k . B o t h d a t a - a n d l i t e r a t u r e - b a s e d f e a t u r e s e l e c t i o n a n d t r a i n e d m o d e l s u s i n g e x t r e m e g r a d i e n t b o o s t i n g m a c h i n e l e a r n i n g w e r e u s e d t o p r e d i c t r i s k o f m a j o r c a r d i o v a s c u l a r e v e n t s ( M A C E s : f a t a l a n d n o n - f a t a l m y o c a r d i a l i n f a r c t i o n , s t r o k e , a n d c o r o n a r y a r t e r y r e v a s c u l a r i z a t i o n ) d u r i n g a 1 0 - y e a r f o l l o w - u p . A r e a u n d e r t h e c u r v e ( A U C ) a n d n e t r e c l a s s i f i c a t i o n i n d e x ( N R I ) w e r e u s e d t o e v a l u a t e t h e a d d i t i v e v a l u e o f s e l e c t e d p r o t e i n p a n e l s t o M A C E p r e d i c t i o n b y S y s t e m a t i c C O r o n a r y R i s k E v a l u a t i o n 2 ( S C O R E 2 ) o r t h e 1 0 T R F s u s e d i n S C O R E 2 . S C O R E 2 a n d S C O R E 2 r e f i t t e d t o U K B i o b a n k d a t a p r e d i c t e d M A C E w i t h A U C s o f 0 . 7 4 0 a n d 0 . 7 4 9 , r e s p e c t i v e l y . D a t a - d r i v e n s e l e c t i o n i d e n t i f i e d 1 1 4 p r o t e i n s o f g r e a t e s t r e l e v a n c e f o r p r e d i c t i o n . P r e d i c t i o n o f M A C E w a s n o t i m p r o v e d b y u s i n g t h e s e p r o t e i n s a l o n e ( A U C o f 0 . 7 5 8 ) b u t w a s s i g n i f i c a n t l y i m p r o v e d b y c o m b i n i n g t h e s e p r o t e i n s w i t h S C O R E 2 o r t h e 1 0 T R F s ( A U C = 0 . 7 7 1 , P < 0 0 1 , N R I = 0 . 1 4 0 , a n d A U C = 0 . 7 6 7 , P = 0 . 0 3 , N R I 0 . 0 5 3 , r e s p e c t i v e l y ) . L i t e r a t u r e - b a s e d p r o t e i n s e l e c t i o n ( 1 1 3 p r o t e i n s f r o m f i v e p r e v i o u s s t u d i e s ) a l s o i m p r o v e d r i s k p r e d i c t i o n b e y o n d T R F s w h i l e a r a n d o m s e l e c t i o n o f 1 1 4 p r o t e i n s d i d n o t . C o n c l u s i o n L a r g e - s c a l e p l a s m a p r o t e o m i c s w i t h d a t a - d r i v e n a n d l i t e r a t u r e - b a s e d p r o t e i n s e l e c t i o n m o d e s t l y i m p r o v e s p r e d i c t i o n o f f u t u r e M A C E b e y o n d T R F s . L a y s u m m a r y T h e r i s k o f h a v i n g a m y o c a r d i a l i n f a r c t i o n o r s t r o k e i s u s u a l l y a s s e s s e d b y c l i n i c a l s c o r e s i n c l u d i n g t r a d i t i o n a l r i s k f a c t o r s f o r c a r d i o v a s c u l a r d i s e a s e . T h e d e v e l o p m e n t o f n e w t e c h n o l o g i e s e n a b l e s t h e r a p i d m e a s u r e m e n t o f a n i n c r e a s i n g n u m b e r o f b l o o d p r o t e i n s . I n t h i s s t u d y , w e a p p l i e d m a c h i n e l e a r n i n g t e c h n i q u e s i n a U K - b a s e d c o h o r t o f 3 8 3 8 0 p a r t i c i p a n t s w i t h 2 9 1 9 b l o o d p r o t e i n s m e a s u r e d . W e o b t a i n e d a s e t o f 1 1 4 p r o t e i n s t h a t i m p r o v e d t h e p r e d i c t i o n o f t h e 1 0 - y e a r r i s k o f m a j o r c a r d i o v a s c u l a r e v e n t w h e n a d d e d t o t r a d i t i o n a l r i s k f a c t o r s . I m p r o v e m e n t s w e r e a l s o a c h i e v e d u s i n g a s e t o f 1 1 3 p r o t e i n s f o u n d i n p r e v i o u s s t u d i e s . H o w e v e r , t h e m a g n i t u d e o f t h e s e i m p r o v e m e n t s w a s r e l a t i v e l y l o w a n d t h e c l i n i c a l u t i l i t y o f c o m b i n i n g t h e s e p r o t e i n s w i t h t r a d i t i o n a l r i s k f a c t o r s i n p r i m a r y p r e v e n t i o n w i l l h a v e t o b e f u r t h e r i n v e s t i g a t e d . ' , ' [ G R A P H I C S ] ' , ' . ' ]

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

Proteomics
Cardiovascular diseases
Risk factors
Machine learning
UK Biobank

Publication and Content Type

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art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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