Sökning: id:"swepub:oai:gup.ub.gu.se/336897" >
Endomyocardial biopsy: safety and prognostic utility in paediatric and adult myocarditis in the European Society of Cardiology EURObservational Research Programme Cardiomyopathy and Myocarditis Long-Term Registry
-
Caforio, Alida L. P. (författare)
-
Kaski, Juan P. (författare)
-
Gimeno, Juan R. (författare)
-
visa fler...
-
Elliott, Perry M. (författare)
-
Laroche, Cecile (författare)
-
Tavazzi, Luigi (författare)
-
Tendera, Michal (författare)
-
- Fu, Michael, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
Sala, Simone (författare)
-
Seferovic, Petar M. (författare)
-
Helio, Tiina (författare)
-
Calo, Leonardo (författare)
-
Blagova, Olga (författare)
-
Amin, Ahmad (författare)
-
Kindermann, Ingrid (författare)
-
Sinagra, Gianfranco (författare)
-
Frustaci, Andrea (författare)
-
Bonnet, Daniel (författare)
-
Maggioni, Aldo P. (författare)
-
Charron, Philippe (författare)
-
visa färre...
-
(creator_code:org_t)
- 2024
- Engelska.
-
Ingår i: EUROPEAN HEART JOURNAL. - 0195-668X .- 1522-9645.
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background and Aims Contemporary multicentre data on clinical and diagnostic spectrum and outcome in myocarditis are limited. Study aims were to describe baseline features, 1-year follow-up, and baseline predictors of outcome in clinically suspected or biopsy-proven myocarditis (2013 European Society of Cardiology criteria) in adult and paediatric patients from the EURObservational Research Programme Cardiomyopathy and Myocarditis Long-Term Registry. Methods Five hundred eighty-one (68.0% male) patients, 493 adults, median age 38 (27-52) years, and 88 children, aged 8 (3-13) years, were divided into 3 groups: Group 1 (n = 233), clinically suspected myocarditis with abnormal cardiac magnetic resonance; Group 2 (n = 222), biopsy-proven myocarditis; and Group 3 (n = 126) clinically suspected myocarditis with normal or inconclusive or no cardiac magnetic resonance. Baseline features were analysed overall, in adults vs. children, and among groups. One-year outcome events included death/heart transplantation, ventricular assist device (VAD) or implantable cardioverter defibrillator (ICD) implantation, and hospitalization for cardiac causes. Results Endomyocardial biopsy, mainly right ventricular, had a similarly low complication rate in children and adults (4.7% vs. 4.9%, P = NS), with no procedure-related death. A classical myocarditis pattern on cardiac magnetic resonance was found in 31.3% of children and in 57.9% of adults with biopsy-proven myocarditis (P < .001). At 1-year follow-up, 11/410 patients (2.7%) died, 7 (1.7%) received a heart transplant, 3 underwent VAD (0.7%), and 16 (3.9%) underwent ICD implantation. Independent predictors at diagnosis of death or heart transplantation or hospitalization or VAD implantation or ICD implantation at 1-year follow-up were lower left ventricular ejection fraction and the need for immunosuppressants for new myocarditis diagnosis refractory to non-aetiology-driven therapy. Conclusions Endomyocardial biopsy was safe, and cardiac magnetic resonance using Lake Louise criteria was less sensitive, particularly in children. Virus-negative lymphocytic myocarditis was predominant both in children and adults, and use of immunosuppressive treatments was low. Lower left ventricular ejection fraction and the need for immunosuppressants at diagnosis were independent predictors of unfavourable outcome events at 1 year.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Myocarditis
- Registry
- Endomyocardial biopsy
- Immunosuppression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- Av författaren/redakt...
-
Caforio, Alida L ...
-
Kaski, Juan P.
-
Gimeno, Juan R.
-
Elliott, Perry M ...
-
Laroche, Cecile
-
Tavazzi, Luigi
-
visa fler...
-
Tendera, Michal
-
Fu, Michael, 196 ...
-
Sala, Simone
-
Seferovic, Petar ...
-
Helio, Tiina
-
Calo, Leonardo
-
Blagova, Olga
-
Amin, Ahmad
-
Kindermann, Ingr ...
-
Sinagra, Gianfra ...
-
Frustaci, Andrea
-
Bonnet, Daniel
-
Maggioni, Aldo P ...
-
Charron, Philipp ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
EUROPEAN HEART J ...
- Av lärosätet
-
Göteborgs universitet