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The role of B cell CD22 expression in Staphylococcus aureus arthritis and sepsis
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- Gjertsson, Inger, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
- Nitschke, L. (author)
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- Tarkowski, Andrej, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
- (creator_code:org_t)
- 2004
- 2004
- English.
- In: Microbes Infect. - 1286-4579. ; 6:4, s. 377-82
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Severe Staphylococcus aureus infections give rise to a pronounced antigen-specific and polyclonal B cell response with elevated serum immunoglobulin levels. However, it has been difficult to correlate the antibody levels with the clinical outcome of sepsis and/or arthritis concerning both protection and pathogenic aspects. Earlier studies have shown that macrophages and neutrophils are of great importance for bacterial clearance. However, deletion of the complete B cell compartment affected neither S. aureus-induced arthritis nor survival. MZ B cells are believed to be of importance for clearance of blood-borne antigens and have been implicated in protection against S. aureus infections. CD22 is a B-cell-specific inhibitory receptor binding to alpha2,6-linked sialic acids, and deficiency in CD22 leads to a 75% reduction of the MZ B cell compartment. CD22-/- mice and congeneic controls were inoculated intravenously with an arthritogenic dose of live S. aureus. No differences between the groups were detected regarding frequency and severity of arthritis, survival, bacterial clearance, or induction of inflammatory response. This study shows explicitly that a reduced MZ B cell compartment in the absence of CD22 expression does not interfere with the inflammatory response during S. aureus infection.
Keyword
- Animals
- Antigens
- CD/genetics/*metabolism
- Antigens
- CD22
- Antigens
- Differentiation
- B-Lymphocyte/genetics/*metabolism
- Arthritis
- Infectious/*immunology/microbiology/mortality/physiopathology
- B-Lymphocytes/*immunology/metabolism
- *Cell Adhesion Molecules
- Disease Models
- Animal
- Humans
- Lectins/genetics/*metabolism
- Mice
- Mice
- Inbred C57BL
- Sepsis/*immunology/microbiology/mortality/physiopathology
- Staphylococcal
- Infections/immunology/microbiology/mortality/physiopathology
- Staphylococcus aureus/*immunology/pathogenicity
Publication and Content Type
- ref (subject category)
- art (subject category)
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