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A single-nucleotide...
A single-nucleotide polymorphism in the XPG gene, and tumour stage, grade, and clinical course in patients with nonmuscle-invasive neoplasms of the urinary bladder
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- Sakano, S. (författare)
- Karolinska Institutet
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- Kumar, R. (författare)
- Karolinska Institutet
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- Larsson, P. (författare)
- Karolinska Institutet
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- Onelov, E. (författare)
- Karolinska Institutet
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- Adolfsson, J. (författare)
- Karolinska Institutet,Karolinska Hospital
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- Steineck, Gunnar, 1952 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Hemminki, K. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: BJU Int. - 1464-4096 .- 1464-410X. ; 97:4, s. 847-51
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To evaluate whether the single nucleotide polymorphism (SNP), Asp1104His (G3507C), in the XPG gene affects malignant phenotypes of nonmuscle-invasive urinary bladder neoplasms (NIBN), by investigating associations between the SNP and clinicopathological variables in patients with NIBN. PATIENTS AND METHODS: The 233 patients constituted newly diagnosed cases of primary NIBN in the Stockholm area. The Asp1104His polymorphism in the XPG gene was genotyped using a polymerase chain reaction-restriction fragment length polymorphism technique. RESULTS: The GC + CC genotypes were more frequent in stage pT1 tumours at initial diagnosis than pTa (odds ratio 1.9, 95% confidence interval 1.0-3.5, P = 0.048). The difference was larger in the young group (4.6, 1.9-11.8, P = 0.001). In the young group, the GC + CC genotypes were significantly more frequent in high-grade than in low-grade tumours (3.1, 1.5-6.8, P = 0.004) whereas in the older group the genotypes were less frequent in high-grade tumours (0.3, 0.1-0.7, P = 0.007). The XPG genotypes were not associated with tumour recurrence, stage progression or survival. CONCLUSION: These results suggest that the SNP in the XPG gene might be related to tumour invasiveness in NIBN.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adult
- Aged
- Aged
- 80 and over
- DNA-Binding Proteins/*genetics
- Disease Progression
- Endonucleases/*genetics
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Nuclear Proteins/*genetics
- Polymerase Chain Reaction
- Polymorphism
- Restriction Fragment Length
- Polymorphism
- Single Nucleotide/*genetics
- Prospective Studies
- Survival Analysis
- Sweden
- Transcription Factors/*genetics
- Urinary Bladder Neoplasms/*genetics
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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BJU Int
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