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Mechanical properties of bacterial cellulose and interactions with smooth muscle cells

Bäckdahl, Henrik, 1977 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Helenius, Gisela, 1973 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg
Bodin, Aase Katarina, 1977 (author)
Chalmers tekniska högskola,Chalmers University of Technology
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Nannmark, Ulf, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg
Johansson, Bengt R, 1947 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg
Risberg, Bo, 1941 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg
Gatenholm, Paul, 1956 (author)
Chalmers tekniska högskola,Chalmers University of Technology
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 (creator_code:org_t)
Elsevier BV, 2006
2006
English.
In: Biomaterials. - : Elsevier BV. - 0142-9612 .- 1878-5905. ; 27:9, s. 2141-2149
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Tissue engineered blood vessels (TEBV) represent an attractive approach for overcoming reconstructive problems associated with vascular diseases by providing small calibre vascular grafts. The aim of this study has been to evaluate a novel biomaterial, bacterial cellulose (BC), as a potential scaffold for TEBV. The morphology of the BC pellicle grown in static culture was investigated with SEM. Mechanical properties of BC were measured in Krebs solution and compared with the properties of porcine carotid arteries and ePTFE grafts. Attachment, proliferation and ingrowth of human smooth muscle cells (SMC) on the BC were analysed in vitro. The BC pellicle had an asymmetric structure composed of a fine network of nanofibrils similar to a collagen network. The shape of the stress-strain response of BC is reminiscent of the stress-strain response of the carotid artery, most probably due to the similarity in architecture of the nanofibrill networks. SMC adhered to and proliferated on the BC pellicle; an ingrowth of up to 40 microm was seen after 2 weeks of culture. BC exhibit attractive properties for use in future TEBV.

Keyword

Adhesins
Bacterial/*pharmacology/*ultrastructure
Animals
*Blood Vessel Prosthesis
Carotid Arteries/cytology
Cell Adhesion
Cell Proliferation
Cells
Cultured
Cellulose/*pharmacology/*ultrastructure
Collagen/pharmacology/ultrastructure
Gluconacetobacter xylinus/metabolism
Myocytes
Smooth Muscle/cytology/*drug effects
Swine
Tensile Strength
Tissue Engineering
Animals

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ref (subject category)
art (subject category)

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