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Requirement of JNK2...
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
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Ricci, R. (author)
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Sumara, G. (author)
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Sumara, I. (author)
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show more...
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Rozenberg, I. (author)
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Kurrer, M. (author)
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Akhmedov, A. (author)
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Hersberger, M. (author)
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Eriksson, U. (author)
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Eberli, F. R. (author)
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Becher, B. (author)
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- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Chen, M. (author)
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Cybulsky, M. I. (author)
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Moore, K. J. (author)
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Freeman, M. W. (author)
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Wagner, E. F. (author)
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Matter, C. M. (author)
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Luscher, T. F. (author)
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: Science. - 1095-9203. ; 306:5701, s. 1558-61
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https://gup.ub.gu.se...
Abstract
Subject headings
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- In vitro studies suggest a role for c-Jun N-terminal kinases (JNKs) in proatherogenic cellular processes. We show that atherosclerosis-prone ApoE-/- mice simultaneously lacking JNK2 (ApoE-/- JNK2-/- mice), but not ApoE-/- JNK1-/- mice, developed less atherosclerosis than do ApoE-/- mice. Pharmacological inhibition of JNK activity efficiently reduced plaque formation. Macrophages lacking JNK2 displayed suppressed foam cell formation caused by defective uptake and degradation of modified lipoproteins and showed increased amounts of the modified lipoprotein-binding and -internalizing scavenger receptor A (SR-A), whose phosphorylation was markedly decreased. Macrophage-restricted deletion of JNK2 was sufficient to decrease atherogenesis. Thus, JNK2-dependent phosphorylation of SR-A promotes uptake of lipids in macrophages, thereby regulating foam cell formation, a critical step in atherogenesis.
Keyword
- Animals
- Antigens
- CD36/metabolism
- Aorta/chemistry/pathology
- Apolipoproteins E/genetics
- Arteriosclerosis/*metabolism/pathology
- Bone Marrow Transplantation
- Cells
- Cultured
- Cholesterol/metabolism
- Cholesterol
- Dietary/administration & dosage
- Diet
- Atherogenic
- Endothelial Cells/physiology
- Foam Cells/*metabolism
- Lipoproteins
- LDL/metabolism
- Macrophages/*metabolism
- Macrophages
- Peritoneal/physiology
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Mitogen-Activated Protein Kinase 8/metabolism
- Mitogen-Activated Protein Kinase 9/genetics/*metabolism
- Muscle
- Smooth
- Vascular/cytology
- Myocytes
- Smooth Muscle/physiology
- Phosphorylation
- Receptors
- Immunologic/genetics/*metabolism
- Receptors
- Scavenger
- Scavenger Receptors
- Class A
- T-Lymphocytes/immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Science
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To the university's database
- By the author/editor
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Ricci, R.
-
Sumara, G.
-
Sumara, I.
-
Rozenberg, I.
-
Kurrer, M.
-
Akhmedov, A.
-
show more...
-
Hersberger, M.
-
Eriksson, U.
-
Eberli, F. R.
-
Becher, B.
-
Borén, Jan, 1963
-
Chen, M.
-
Cybulsky, M. I.
-
Moore, K. J.
-
Freeman, M. W.
-
Wagner, E. F.
-
Matter, C. M.
-
Luscher, T. F.
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show less...
- Articles in the publication
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Science
- By the university
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University of Gothenburg