Antibody prevalence and titer to norovirus (genogroup II) correlate with secretor (FUT2) but not with ABO phenotype or Lewis (FUT3) genotype

Modin Larsson, Malin, 1980- (author): Linköpings universitet,Molekylär virologi,Hälsouniversitetet

Rydell, Gustaf E (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg

Grahn, Ammi, 1961 (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg

Rodriguez-Diaz, J. (author): Linköpings universitet,Molekylär virologi,Hälsouniversitetet

Åkerlind, Britt (author): Östergötlands Läns Landsting,Linköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet

Hutson, A. M. (author): Departments of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

Estes, M. K. (author): Departments of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

Larson, Göran, 1953 (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg

Svensson, Lennart (author): Linköpings universitet,Molekylär virologi,Hälsouniversitetet

(creator_code:org_t)

Related links:: https://gup.ub.gu.se...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

BACKGROUND: Histo-blood group antigens and secretor status have been associated with susceptibility to Norovirus infections, which suggests that antibody prevalence and titer might correlate with these phenotypes. METHODS: Plasma samples (n = 105) from Swedish blood donors that had been genotyped for secretor (FUT2) and Lewis (Le; FUT3) genotypes and phenotyped for ABO and Le blood groups were analyzed for immunoglobulin G antibody prevalence and titers to norovirus genogroup (GG) II.4. RESULTS: The results showed that nonsecretors (se4128se428) and Lea+b- individuals not only had significantly lower antibody titers than did secretors (P < .0001) and Lea-b+ individuals (P < .0002) but were also significantly more often antibody negative (P < .05). Antibody titers in secretors were not significantly different between individuals of different Le (FUT3) genotypes or different ABO phenotypes. CONCLUSIONS: Nonsecretors and Lea+b- individuals are significantly less prone to be infected with GGII noroviruses. This new information extends previous knowledge and supports the hypothesis that nonsecretors are relatively but not absolutely resistant to norovirus infections.

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

By the author/editor: Modin Larsson, M ...; Rydell, Gustaf E; Grahn, Ammi, 196 ...; Rodriguez-Diaz, ...; Åkerlind, Britt; Hutson, A. M.; show more...; Estes, M. K.; Larson, Göran, 1 ...; Svensson, Lennar ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

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