Sökning: id:"swepub:oai:gup.ub.gu.se/53012" > Ghrelin stimulates ...
Fältnamn | Indikatorer | Metadata |
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000 | 05593naa a2200817 4500 | |
001 | oai:gup.ub.gu.se/53012 | |
003 | SwePub | |
008 | 240528s2006 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/530122 URI |
024 | 7 | a https://doi.org/10.1111/j.1369-1600.2006.00002.x2 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jerlhag, Elisabeth,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology4 aut0 (Swepub:gu)xjerel |
245 | 1 0 | a Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward. |
264 | 1 | b Wiley,c 2006 |
520 | a It is becoming increasingly apparent that there is a degree of neurochemical overlap between the reward systems and those regulating energy balance. We therefore investigated whether ghrelin, a stomach-derived and centrally derived orexigenic peptide, might act on the reward systems. Central ghrelin administration (1 microg/microL, to the third ventricle) induced an acute increase in locomotor activity as well as dopamine-overflow in the nucleus accumbens, suggesting that ghrelin can activate the mesoaccumbal dopamine system originating in the ventral tegmental area, a system associated with reward and motivated behaviour. The cholinergic afferents to the ventral tegmental area have been implicated in natural reward and in regulating mesoaccumbal dopamine neurons. The possibility that nicotinic receptors are involved in mediating the stimulatory and dopamine-enhancing effects of ghrelin is supported by the findings that peripheral injection of the unselective nicotinic antagonist mecamylamine (2.0 mg/kg) blocked these ghrelin-induced effects. Tentatively, ghrelin may, via activation of the acetylcholine-dopamine reward link, increase the incentive values of signals associated with motivated behaviours of importance for survival such as feeding behaviour. It will be important to discover whether this has therapeutic implications for compulsive addictive behaviours, such as eating behaviour disorders and drug dependence. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
653 | a Afferent Pathways | |
653 | a drug effects | |
653 | a physiopathology | |
653 | a Animals | |
653 | a Brain | |
653 | a physiopathology | |
653 | a Cholinergic Fibers | |
653 | a drug effects | |
653 | a physiology | |
653 | a Dopamine | |
653 | a metabolism | |
653 | a Eating Disorders | |
653 | a physiopathology | |
653 | a Injections | |
653 | a Intraventricular | |
653 | a Male | |
653 | a Mecamylamine | |
653 | a pharmacology | |
653 | a Mice | |
653 | a Mice | |
653 | a Inbred Strains | |
653 | a Motor Activity | |
653 | a drug effects | |
653 | a physiology | |
653 | a Nucleus Accumbens | |
653 | a drug effects | |
653 | a physiopathology | |
653 | a Peptide Hormones | |
653 | a pharmacology | |
653 | a Receptors | |
653 | a Nicotinic | |
653 | a drug effects | |
653 | a physiology | |
653 | a Reward | |
653 | a Substance-Related Disorders | |
653 | a physiopathology | |
653 | a Tegmentum Mesencephali | |
653 | a drug effects | |
653 | a physiology | |
700 | 1 | a Egecioglu, Emil,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xegeem |
700 | 1 | a Dickson, Suzanne L.,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xdicsu |
700 | 1 | a Andersson, Malin E,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xamalv |
700 | 1 | a Svensson, Lennart,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology4 aut0 (Swepub:gu)xsvenl |
700 | 1 | a Engel, Jörgen,d 1942u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology4 aut0 (Swepub:gu)xenjor |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi4 org |
773 | 0 | t Addiction biologyd : Wileyg 11:1, s. 45-54q 11:1<45-54x 1355-6215x 1369-1600 |
856 | 4 8 | u https://gup.ub.gu.se/publication/53012 |
856 | 4 8 | u https://doi.org/10.1111/j.1369-1600.2006.00002.x |
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