Sökning: id:"swepub:oai:gup.ub.gu.se/53514" >
Off-pump CABG reduc...
Off-pump CABG reduces complement activation but does not significantly affect peripheral endothelial function: a prospective randomized study.
-
Johansson-Synnergren, Mats, 1968 (författare)
-
- Nilsson, Folke, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
-
- Bengtsson, Anders, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
-
visa fler...
-
- Jeppsson, Anders, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
-
- Wiklund, Lars, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
-
visa färre...
-
(creator_code:org_t)
- 2009-07-12
- 2004
- Engelska.
-
Ingår i: Scandinavian cardiovascular journal : SCJ. - : Informa UK Limited. - 1401-7431 .- 1651-2006. ; 38:1, s. 53-8
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE--Cardiac surgery initiates a systemic inflammatory response, which may affect endothelial function. The aim of this study was to investigate if off-pump CABG (OPCAB) reduces the postoperative inflammatory response and affects endothelial function less than conventional on-pump CABG. DESIGN--Fifty-two patients submitted for elective CABG were included in a prospective, randomized study. Twenty-six patients were operated with, and 26 without cardiopulmonary bypass (CPB). Plasma levels of complement (C3a), cytokines (IL-8, TNF-alpha), endothelin-1 and neopterin were measured before and during surgery and 2 and 24 h after surgery. Endothelial function was assessed by forearm plethysmography and acetylcholine infusion in 30 patients 2-4 h after surgery. RESULTS--C3a and neopterin concentrations were significantly higher during and early after surgery in the CPB group while TNF-alpha and IL-8 tended to be higher in the CPB group but the difference did not reach statistical significance. Endothelial function did not differ significantly between the two groups. CONCLUSION--OPCAB reduces complement activation compared with on-pump CABG but does not significantly affect TNF-alpha and IL-8 release or endothelial function.
Nyckelord
- Acetylcholine
- administration & dosage
- Area Under Curve
- Biological Markers
- blood
- Cardiopulmonary Bypass
- Complement Activation
- drug effects
- physiology
- Complement C3a
- drug effects
- metabolism
- Coronary Artery Bypass
- Dose-Response Relationship
- Drug
- Endothelin-1
- blood
- drug effects
- Endothelium
- Vascular
- metabolism
- physiopathology
- surgery
- Female
- Forearm
- blood supply
- Humans
- Interleukin-8
- blood
- Male
- Middle Aged
- Neopterin
- blood
- Nitroprusside
- administration & dosage
- Prospective Studies
- Regional Blood Flow
- drug effects
- physiology
- Treatment Outcome
- Tumor Necrosis Factor-alpha
- drug effects
- metabolism
- Vasodilation
- drug effects
- physiology
- Vasodilator Agents
- administration & dosage
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas