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The fragrance chemical beta-caryophyllene-air oxidation and skin sensitization.
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- Sköld, Maria, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
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- Karlberg, Ann-Therese, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
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- Matura, Mihaly, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
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- (creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
- In: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. - : Elsevier BV. - 0278-6915. ; 44:4, s. 538-45
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Fragrances are common causes of allergic contact dermatitis. beta-Caryophyllene is a sesquiterpene that is used as a fragrance chemical. Analogous to the monoterpenes R-limonene and linalool, it can be expected to autoxidize when air exposed. The aim of the present study was to investigate the autoxidation of beta-caryophyllene and to evaluate the effect on the contact allergenic activity. beta-Caryophyllene started to oxidize immediately when air exposed and after 5 weeks almost 50% of the original compound was consumed. Caryophyllene oxide was found to be the major oxidation product. Hydroperoxides of beta-caryophyllene could not be detected in the oxidation mixture. Caryophyllene oxide was shown to be an allergen of moderate strength and beta-caryophyllene air exposed for 10 weeks showed a weak sensitizing capacity in the local lymph node assay. The study reveals that the allergenic activity of beta-caryophyllene is affected by autoxidation, but to a lesser extent when compared to R-limonene and linalool. The present findings support our results in clinical studies showing oxidized beta-caryophyllene to be a rather rare sensitizer compared to oxidized R-limonene and linalool.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- Air
- Animals
- Dermatitis
- Contact
- etiology
- pathology
- Female
- Guinea Pigs
- Mice
- Mice
- Inbred CBA
- Oxidation-Reduction
- Perfume
- adverse effects
- chemistry
- Sesquiterpenes
- adverse effects
- chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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- University of Gothenburg
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