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Sökning: id:"swepub:oai:gup.ub.gu.se/56081" > Albuminuria predict...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003663naa a2200553 4500
001oai:gup.ub.gu.se/56081
003SwePub
008240528s2004 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/560812 URI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Olsen, M. H.4 aut
2451 0a Albuminuria predicts cardiovascular events independently of left ventricular mass in hypertension: a LIFE substudy
264 1c 2004
520 a We wanted to investigate whether urine albumin/creatinine ratio (UACR) and left ventricular (LV) mass, both being associated with diabetes and increased blood pressure, predicted cardiovascular events in patients with hypertension independently. After 2 weeks of placebo treatment, clinical, laboratory and echocardiographic variables were assessed in 960 hypertensive patients from the LIFE Echo substudy with electrocardiographic LV hypertrophy. Morning urine albumin and creatinine were measured to calculate UACR. The patients were followed for 60+/-4 months and the composite end point (CEP) of cardiovascular (CV) death, nonfatal stroke or nonfatal myocardial infarction was recorded. The incidence of CEP increased with increasing LV mass (below the lower quartile of 194 g to above the upper quartile of 263 g) in patients with UACR below (6.7, 5.0, 9.1%) and above the median value of 1.406 mg/mmol (9.7, 17.0, 19.0%(***)). Also the incidence of CV death increased with LV mass in patients with UACR below (0, 1.4, 1.3%) and above 1.406 mg/mmol (2.2, 6.4, 8.0%(**)). The incidence of CEP was predicted by logUACR (hazard ratio (HR)=1.44(**) for every 10-fold increase in UACR) after adjustment for Framingham risk score (HR=1.05(***)), history of peripheral vascular disease (HR=2.3(*)) and cerebrovascular disease (HR=2.1(*)). LV mass did not enter the model. LogUACR predicted CV death (HR=2.4(**)) independently of LV mass (HR=1.01(*) per gram) after adjustment for Framingham risk score (HR=1.05(*)), history of diabetes mellitus (HR=2.4(*)) and cerebrovascular disease (HR=3.2(*)). (*)P<0.05, (**)P<0.01, (***)P<0.001. In conclusion, UACR predicted CEP and CV death independently of LV mass. CV death was predicted by UACR and LV mass in an additive manner after adjustment for Framingham risk score and history of CV disease.
653 a Aged
653 a Aged
653 a 80 and over
653 a Albuminuria/*complications
653 a Cerebrovascular Accident/*etiology
653 a Creatinine/*urine
653 a Death
653 a Sudden
653 a Cardiac/*etiology
653 a Female
653 a Heart Ventricles/ultrasonography
653 a Humans
653 a Hypertension/complications
653 a Hypertrophy
653 a Left Ventricular/*complications/ultrasonography
653 a Male
653 a Middle Aged
653 a Myocardial Infarction/*etiology
653 a Predictive Value of Tests
7001 a Wachtell, K.4 aut
7001 a Bella, J. N.4 aut
7001 a Palmieri, V.4 aut
7001 a Gerdts, E.4 aut
7001 a Smith, G.4 aut
7001 a Nieminen, M. S.4 aut
7001 a Dahlöf, Björn,d 1953u Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute4 aut0 (Swepub:gu)xdahbj
7001 a Ibsen, H.4 aut
7001 a Devereux, R. B.4 aut
7102 a Göteborgs universitetb Hjärt-kärlinstitutionen4 org
7730 t J Hum Hypertensg 18:6, s. 453-9q 18:6<453-9x 0950-9240
8564 8u https://gup.ub.gu.se/publication/56081

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