The Synthesis and Biological Evaluation of Two Analogues of the C-Riboside Showdomycin

Renner, Jens (author)

Kruszelnicki, Irma (author)

Adamiak, Beata (author): Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology

Willis, Anthony C (author)

Hammond, Edward (author)

Su, Stephen (author)

Burns, Christopher (author)

Trybala, Edward, 1955 (author): Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology

Ferro, Vito (author)

Banwell, Martin G (author)

(creator_code:org_t)

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Two novel analogues, 2 and 3, of the C-riboside showdomycin (1) have been prepared by exploiting the N-TIPS-substituted pyrrole 7 as a synthetic equivalent for the maleimide C3 anion. The tetraacetate precursor, 12, of target 2 as well as target 3 itself were subjected to single-crystal X-ray analyses. Analogues 2 and 3 as well as showdomycin and its anomer (4) have each been evaluated in various assays for their cytotoxic, anti-bacterial, and anti-viral effects.

By the author/editor: Renner, Jens; Kruszelnicki, Ir ...; Adamiak, Beata; Willis, Anthony ...; Hammond, Edward; Su, Stephen; show more...; Burns, Christoph ...; Trybala, Edward, ...; Ferro, Vito; Banwell, Martin ...; show less...

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