Search: id:"swepub:oai:gup.ub.gu.se/60167" >
Beneficial effect o...
Beneficial effect of angiotensin-converting enzyme inhibitor on dilated cardiomyopathy induced by autoimmune mechanism against beta1-adrenoceptor.
-
Matsui, S (author)
-
- Fu, Michael, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Wallenberglaboratoriet,Institute of Internal Medicine,Wallenberg Laboratory
-
Hayase, M (author)
-
show more...
-
Katsuda, T (author)
-
Yamaguchi, N (author)
-
Teraoka, K (author)
-
Kurihara, T (author)
-
Takekoshi, N (author)
-
Wakabayashi, H (author)
-
show less...
-
(creator_code:org_t)
- 2000
- 2000
- English.
-
In: Journal of cardiovascular pharmacology. - 0160-2446. ; 36 Suppl 2
- Related links:
-
https://gup.ub.gu.se...
Abstract
Subject headings
Close
- We have shown that a peptide corresponding to the sequence of the second extracellular loop of the human beta1-adrenoceptor (beta1-peptide) was able to induce an autoimmune cardiomyopathy in rabbits. In this study, we examined the effect of angiotensin-converting enzyme inhibitor (ACEI) on beta1-peptide-induced cardiomyopathy. Rabbits were divided into four groups: (1) control group (n= 6) receiving saline injection; (2) beta1-peptide group (n = 8) immunized with beta1-peptide; (3) ACEI group (n = 6), lisinopril (3 mg/day) given orally and receiving saline injection; and (4) ACEI + beta1-peptide group (n = 7), lisinopril (3 mg/day) given orally and immunized with beta1-peptide. Our results showed that, after 1 year, all rabbits in the beta1-peptide group had an increase in heart weight, wall thinning and dilatations of both ventricles as compared with rabbits in the ACEI + beta1-peptide group that had normal heart weight and shape. All rabbits in the beta1-peptide group exhibited multifocal degeneration and necrosis of myocardial cells with moderate infiltration of inflammatory cells. In the ACEI + beta1-peptide group, three rabbits showed focal degeneration and necrosis of myocardial cells accompanied by mononuclear cells. The lesions in this group were apparently less marked than those in the beta1-peptide group. In conclusion, ACEI protects the myocardium from injury induced by an autoimmune mechanism against beta1-adrenoceptor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Amino Acid Sequence
- Angiotensin-Converting Enzyme Inhibitors
- therapeutic use
- Animals
- Autoimmunity
- Body Weight
- drug effects
- Cardiomyopathy
- Dilated
- drug therapy
- etiology
- Enzyme-Linked Immunosorbent Assay
- Immunization
- Lisinopril
- blood
- therapeutic use
- Microscopy
- Electron
- Molecular Sequence Data
- Myocardium
- pathology
- ultrastructure
- Organ Size
- drug effects
- Rabbits
- Receptors
- Adrenergic
- beta-1
- immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Matsui, S
-
Fu, Michael, 196 ...
-
Hayase, M
-
Katsuda, T
-
Yamaguchi, N
-
Teraoka, K
-
show more...
-
Kurihara, T
-
Takekoshi, N
-
Wakabayashi, H
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Physiology
- Articles in the publication
-
Journal of cardi ...
- By the university
-
University of Gothenburg