id:"swepub:oai:gup.ub.gu.se/75336"
Search: id:"swepub:oai:gup.ub.gu.se/75336" > Raloxifene- and est...
- 1 of 1
- Previous record
- Next record
- To hitlist
Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice.
- Erlandsson, M C (author)
- Jonsson, C A (author)
-
- Lindberg, Marie K, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
- show more...
- show less...
- (creator_code:org_t)
- 2002
- 2002
- English.
- In: The Journal of endocrinology. - 0022-0795. ; 175:2, s. 319-27
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Raloxifene is a selective estrogen receptor modulator approved for the prevention of osteoporosis in postmenopausal women. It is selective by having estrogen-agonistic effects on bone, vessels and blood lipids while it is antagonistic on mammary and uterine tissue. Our aim was to study the agonistic and antagonistic properties of the raloxifene analogue LY117018 (LY) on uterus, bone, B lymphopoiesis and B cell function. Oophorectomized and sham-operated animals were treated with s.c. injections of equipotent anti-osteoporotic doses of 17beta-estradiol (E2) (0.1 mg/kg) or LY (3 mg/kg) or vehicle as controls. Effects on bone mineral density (BMD) were studied using peripheral quantitative computed tomography, uterine weight was examined, B lymphopoiesis was examined using flow cytometry and B cell function in bone marrow and spleen was studied by the use of an ELISPOT assay. E2 and LY had similar effects on BMD and bone marrow B lymphopoiesis, while LY had a clear antagonistic effect on endogenous estrogen in uterine tissue and no stimulating effect on the frequency of Ig-producing B cells in sham-operated animals. Our results are discussed in the context of estrogen receptor biology, relations between the immune system and bone metabolism and also with respect to the estrogen-mediated effects on rheumatic diseases.
Keyword
- Animals
- B-Lymphocytes
- drug effects
- Bone and Bones
- drug effects
- Estradiol
- pharmacology
- Female
- Flow Cytometry
- Immunoenzyme Techniques
- methods
- Insulin-Like Growth Factor I
- drug effects
- Lymphopoiesis
- drug effects
- Mice
- Mice
- Inbred C57BL
- Pyrrolidines
- pharmacology
- Selective Estrogen Receptor Modulators
- pharmacology
- Spleen
- drug effects
- Thiophenes
- pharmacology
- Tomography
- X-Ray Computed
- Uterus
- drug effects
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- The Journal of endocrinology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Erlandsson, M C
- Jonsson, C A
- Lindberg, Marie ...
- Ohlsson, Claes, ...
- Carlsten, Hans, ...
- Articles in the publication
- The Journal of e ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
