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Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: a longitudinal study
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- Gisslén, Magnus, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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- Hagberg, Lars, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
- Fuchs, Dietmar (author)
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- (creator_code:org_t)
- 1998
- 1998
- English.
- In: J Acquir Immune Defic Syndr Hum Retrovirol. ; 17:4, s. 291-5
- Journal article (peer-reviewed)
Abstract
Subject headings
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- HIV-1 RNA and neopterin levels were observed longitudinally for 20 to 68 months (mean, 37.5 months) in cerebrospinal fluid (CSF) and serum in 15 HIV-1-infected patients not receiving antiretroviral treatment. During the course of infection the HIV-1 RNA levels increased significantly in CSF, from a mean of 3.08 to 3.51 log10 copies RNA/ml (p < .01). A significant positive correlation was found between the CSF levels of HIV-I RNA and neopterin (rs = 0.54; p < .001), which increased from 13.6 to 19.6 nmol/L (p < .01). No significant changes in HIV-1 RNA or neopterin levels were found in serum. We suggest that the increase of CSF viral load with time in HIV-1 infection triggers an intrathecal immune activation reflected by increased CSF levels of neopterin. These results are in accordance with the theory that a chronic immune stimulation within the central nervous system (CNS) is involved in the pathogenesis of neurologic HIV-1 disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Adult
- CD4 Lymphocyte Count
- Cerebrospinal Fluid/*virology
- Cohort Studies
- Female
- Follow-Up Studies
- HIV Infections/cerebrospinal fluid/immunology/*virology
- HIV-1/genetics/immunology/*physiology
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Neopterin/blood/cerebrospinal fluid
- Polymerase Chain Reaction
- RNA
- Viral/blood/*cerebrospinal fluid
- *Viral Load
Publication and Content Type
- ref (subject category)
- art (subject category)
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