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Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis.
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- Calander, Ann-Marie, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
- Starckx, Sofie (author)
- Opdenakker, Ghislain (author)
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- Elsevier BV, 2006
- 2006
- English.
- In: Microbes and infection / Institut Pasteur. - : Elsevier BV. - 1286-4579. ; 8:6, s. 1434-9
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Matrix metalloproteinases constitute a family of structurally related endopeptidases that are crucial for the normal turnover of the extracellular matrix. Elevated levels of MMP-9 have been demonstrated in synovial fluids of rheumatoid arthritis patients, and a correlation with the severity of the disease has been described. The aim of this study was to explore the impact of MMP-9 expression on joint inflammation and destruction in a model of bacterially induced septic arthritis. MMP-9 knock-out mice and C57Bl6 congenic controls were inoculated intravenously or intra-articularly with Staphylococcus aureus. Arthritis was evaluated clinically and by means of histology. Zymographic analyses were performed to study ex vivo induction of MMP-9 following exposure to S. aureus. The MMP-9 knock-out mice displayed a significantly higher frequency and severity, but not destructivity, of arthritis than did the wild-type mice. The knock-out mice also proved to harbour an increased number of bacteria locally in joints and systemically in kidneys, possibly by impaired extravasation and recruitment of leukocytes and a deficient early defence against infection. Our findings indicate that deficiency in MMP-9 increases the degree of joint inflammation due to decreased bacterial clearance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Animals
- Arthritis
- Infectious
- enzymology
- immunology
- microbiology
- pathology
- Cell Growth Processes
- physiology
- Disease Models
- Animal
- Electrophoresis
- Polyacrylamide Gel
- Female
- Histocytochemistry
- Interleukin-6
- metabolism
- Joints
- enzymology
- immunology
- microbiology
- pathology
- Matrix Metalloproteinase 9
- deficiency
- immunology
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Staphylococcal Infections
- enzymology
- immunology
- microbiology
- Staphylococcus aureus
- immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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