id:"swepub:oai:lup.lub.lu.se:03f648b3-37fe-4410-a717-45178efc99c1"
Sökning: id:"swepub:oai:lup.lub.lu.se:03f648b3-37fe-4410-a717-45178efc99c1" > The WNT5A Agonist F...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03924naa a2200409 4500 | |
| 001 | oai:lup.lub.lu.se:03f648b3-37fe-4410-a717-45178efc99c1 | |
| 003 | SwePub | |
| 008 | 190503s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/03f648b3-37fe-4410-a717-45178efc99c12 URI |
| 024 | 7 | a https://doi.org/10.21873/anticanres.132782 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Osman, Janinau Lund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-jao |
| 245 | 1 0 | a The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer |
| 264 | c 2019-04-05 | |
| 264 | 1 | b Anticancer Research USA Inc.c 2019 |
| 300 | a 10 s. | |
| 520 | a BACKGROUND: The wingless-type mammary tumour virus integration site 5A (WNT5A) agonist Foxy5 was shown in vitro to affect intracellular signalling implicated in the regulation of colonic cancer stem cells (CSCs). MATERIALS AND METHODS: In order to study whether Foxy5 can modulate CSCs, either HT-29 or Caco-2 human colonic cancer cells, both lacking endogenous WNT5A expression, were inoculated subcutaneously into nude mice. RESULTS: Foxy5 reduced the expression of the stem-cell marker aldehyde dehydrogenase and, interestingly, the specific colon CSC marker double cortin-like kinase 1. Foxy5 also reduced active β-catenin and the expression of its downstream target Achaete Scute complex homolog 2, a CSC-preserving transcription factor. Foxy5 also reduced cyclo-oxygenase 2 expression, responsible for the formation of the CSC-promoting prostaglandin E2 (PGE2), but increased that of 15-hydroxyprostaglandin dehydrogenase expression, a PGE2-degrading enzyme. Accordingly, Foxy5 impairs both β-catenin and PGE2 signalling, both of which have been implicated in promoting the niche of colonic CSCs. CONCLUSION: Our data suggest that Foxy5 can complement the traditional adjuvant chemotherapeutic treatment to which CSCs are resistant. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a cancer stem cells | |
| 653 | a Foxy5 peptide | |
| 653 | a tumour cell signalling | |
| 653 | a WNT5A | |
| 700 | 1 | a Bellamkonda, Kishanu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-kbl |
| 700 | 1 | a Liu, Qingu Lund University,Lunds universitet,Experimentell patologi, Malmö,Forskargrupper vid Lunds universitet,Experimental Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-qli |
| 700 | 1 | a Andersson, Tommyu Lund University,Lunds universitet,Experimentell patologi, Malmö,Forskargrupper vid Lunds universitet,Experimental Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)expp-tan |
| 700 | 1 | a Sjölander, Anitau Lund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)expp-asj |
| 710 | 2 | a Cellpatologi, Malmöb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Anticancer researchd : Anticancer Research USA Inc.g 39:4, s. 1719-1728q 39:4<1719-1728x 1791-7530x 0250-7005 |
| 856 | 4 | u http://dx.doi.org/10.21873/anticanres.13278y FULLTEXT |
| 856 | 4 | u http://ar.iiarjournals.org/content/39/4/1719.full.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/03f648b3-37fe-4410-a717-45178efc99c1 |
| 856 | 4 8 | u https://doi.org/10.21873/anticanres.13278 |
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