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Characterizing motor and non-motor aspects of early-morning off periods in Parkinson's disease: An international multicenter study.
- Rizos, A (author)
- Martinez-Martin, P (author)
-
- Odin, Per (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Antonini, A (author)
- Kessel, B (author)
- Kozul, T Klemencic (author)
- Todorova, A (author)
- Douiri, A (author)
- Martin, A (author)
- Stocchi, F (author)
- Dietrichs, E (author)
- Chaudhuri, K Ray (author)
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- (creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
- In: Parkinsonism & Related Disorders. - : Elsevier BV. - 1873-5126 .- 1353-8020. ; 20:11, s. 1231-1235
- Journal article (peer-reviewed)
Abstract
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- The characteristic off periods that develop over time in subjects with Parkinson's disease (PD) on chronic levodopa therapy are usually considered to be motor complications but more recently the important contribution of non-motor off and non-motor fluctuations has also been acknowledged. Early-morning off (EMO) periods in PD patients are known to be a cause of significant disability, in addition to having a negative impact on quality of life. Yet EMOs are poorly defined, particularly in relation to non-motor symptoms (NMS).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- ref (subject category)
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- Rizos, A
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- Odin, Per
- Antonini, A
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- Kozul, T Klemenc ...
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- Todorova, A
- Douiri, A
- Martin, A
- Stocchi, F
- Dietrichs, E
- Chaudhuri, K Ray
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