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id:"swepub:oai:lup.lub.lu.se:0b1e5557-2a55-4e50-bf36-2e389ea8abd2"
 

Sökning: id:"swepub:oai:lup.lub.lu.se:0b1e5557-2a55-4e50-bf36-2e389ea8abd2" > Studies on the Prot...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003347naa a2200385 4500
001oai:lup.lub.lu.se:0b1e5557-2a55-4e50-bf36-2e389ea8abd2
003SwePub
008180205s2018 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/0b1e5557-2a55-4e50-bf36-2e389ea8abd22 URI
0247 a https://doi.org/10.1038/s41598-018-20041-92 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Adav, Sunil S.u Nanyang Technological University4 aut
2451 0a Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins
264 c 2018-01-25
264 1b Springer Science and Business Media LLC,c 2018
520 a Human hair is laminar-fibrous tissue and an evolutionarily old keratinization product of follicle trichocytes. Studies on the hair proteome can give new insights into hair function and lead to the development of novel biomarkers for hair in health and disease. Human hair proteins were extracted by detergent and detergent-free techniques. We adopted a shotgun proteomics approach, which demonstrated a large extractability and variety of hair proteins after detergent extraction. We found an enrichment of keratin, keratin-associated proteins (KAPs), and intermediate filament proteins, which were part of protein networks associated with response to stress, innate immunity, epidermis development, and the hair cycle. Our analysis also revealed a significant deamidation of keratin type I and II, and KAPs. The hair shafts were found to contain several types of histones, which are well known to exert antimicrobial activity. Analysis of the hair proteome, particularly its composition, protein abundances, deamidated hair proteins, and modification sites, may offer a novel approach to explore potential biomarkers of hair health quality, hair diseases, and aging.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
7001 a Subbaiaih, Roopa S.u Nanyang Technological University4 aut
7001 a Kerk, Swat Kimu Nanyang Technological University4 aut
7001 a Lee, Amelia Yilinu Nanyang Technological University4 aut
7001 a Lai, Hui Yingu Nanyang Technological University4 aut
7001 a Ng, Kee Woeiu Nanyang Technological University,Skin Research Institute of Singapore4 aut
7001 a Sze, Siu Kwanu Nanyang Technological University4 aut
7001 a Schmidtchen, Arturu Lund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Nanyang Technological University,University of Copenhagen4 aut0 (Swepub:lu)derm-asc
7102 a Nanyang Technological Universityb Skin Research Institute of Singapore4 org
7730 t Scientific Reportsd : Springer Science and Business Media LLCg 8:1q 8:1x 2045-2322
8564 u http://dx.doi.org/10.1038/s41598-018-20041-9x freey FULLTEXT
8564 u https://www.nature.com/articles/s41598-018-20041-9.pdf
8564 8u https://lup.lub.lu.se/record/0b1e5557-2a55-4e50-bf36-2e389ea8abd2
8564 8u https://doi.org/10.1038/s41598-018-20041-9

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