Search: id:"swepub:oai:lup.lub.lu.se:0c191942-2da0-48c1-8a01-4869a6c02d7a" >
Mutation of the key...
Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice
-
- Chen, Jun (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Kumamoto University
-
- Kaitsuka, Taku (author)
- Kumamoto University
-
- Fujino, Rika (author)
- Kumamoto University
-
show more...
-
- Araki, Kimi (author)
- Kumamoto University
-
- Tomizawa, Kazuhito (author)
- Kumamoto University
-
- Yamamoto, Tetsuro (author)
- Kumamoto University
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English 6 s.
-
In: Neuroscience Letters. - : Elsevier BV. - 0304-3940. ; 629, s. 221-226
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
http://manuscript.el...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Anxiety-like behavior
- Complement system
- Extraribosomal function
- Fear memory
- Grooming behavior
- Ribosomal protein S19
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database