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Sökning: onr:"swepub:oai:lup.lub.lu.se:113bb48c-9634-4157-8f7d-d57b8a3b8997" > Impact of progressi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005285naa a2200661 4500
001oai:lup.lub.lu.se:113bb48c-9634-4157-8f7d-d57b8a3b8997
003SwePub
008221010s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:150014361
0247 a https://lup.lub.lu.se/record/113bb48c-9634-4157-8f7d-d57b8a3b89972 URI
0247 a https://doi.org/10.1007/s00380-022-02111-12 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1500143612 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Gasparovic, Hrvoje4 aut
2451 0a Impact of progressive aortic regurgitation on outcomes after left ventricular assist device implantation
264 c 2022-06-23
264 1b Springer Science and Business Media LLC,c 2022
520 a Aortic regurgitation (AR) following continuous flow left ventricular assist device implantation (cf-LVAD) may adversely impact outcomes. We aimed to assess the incidence and impact of progressive AR after cf-LVAD on prognosis, biomarkers, functional capacity and echocardiographic findings. In an analysis of the PCHF-VAD database encompassing 12 European heart failure centers, patients were dichotomized according to the progression of AR following LVAD implantation. Patients with de-novo AR or AR progression (AR_1) were compared to patients without worsening AR (AR_0). Among 396 patients (mean age 53 ± 12 years, 82% male), 153 (39%) experienced progression of AR over a median of 1.4 years on LVAD support. Before LVAD implantation, AR_1 patients were less frequently diabetic, had lower body mass indices and higher baseline NT-proBNP values. Progressive AR did not adversely impact mortality (26% in both groups, HR 0.91 [95% CI 0.61–1.36]; P = 0.65). No intergroup variability was observed in NT-proBNP values and 6-minute walk test results at index hospitalization discharge and at 6-month follow-up. However, AR_1 patients were more likely to remain in NYHA class III and had worse right ventricular function at 6-month follow-up. Lack of aortic valve opening was related to de-novo or worsening AR (P < 0.001), irrespective of systolic blood pressure (P = 0.67). Patients commonly experience de-novo or worsening AR when exposed to continuous flow of contemporary LVADs. While reducing effective forward flow, worsening AR did not influence survival. However, less complete functional recovery and worse RV performance among AR_1 patients were observed. Lack of aortic valve opening was associated with progressive AR.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Aortic regurgitation
653 a Left ventricular assist device
653 a Outcome
7001 a Jakus, Nina4 aut
7001 a Brugts, Jasper J.u Erasmus University Medical Center4 aut
7001 a Pouleur, Anne Catherineu Catholic University of Louvain,Saint-Luc University Hospital4 aut
7001 a Timmermans, Philippeu University Hospitals Leuven4 aut
7001 a Rubiś, Pawelu Jagiellonian University4 aut
7001 a Gaizauskas, Edvinasu Vilnius University4 aut
7001 a Van Craenenbroeck, Emeline M.u Antwerp University Hospital4 aut
7001 a Barge-Caballero, Eduardo4 aut
7001 a Grundmann, Sebastian4 aut
7001 a Paolillo, Stefaniau University of Naples Federico II4 aut
7001 a D’Amario, Domenico4 aut
7001 a Braun, Oscaru Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kard-oos
7001 a Meyns, Bartu University Hospitals Leuven4 aut
7001 a Droogne, Walteru University Hospitals Leuven4 aut
7001 a Wierzbicki, Karolu Jagiellonian University4 aut
7001 a Holcman, Katarzynau Jagiellonian University4 aut
7001 a Planinc, Ivo4 aut
7001 a Lovric, Daniel4 aut
7001 a Flammer, Andreas J.u University Hospital of Zurich4 aut
7001 a Petricevic, Mate4 aut
7001 a Biocina, Bojan4 aut
7001 a Lund, Lars H.u Karolinska Institutet,Karolinska Institute4 aut
7001 a Milicic, Davor4 aut
7001 a Ruschitzka, Franku University Hospital of Zurich4 aut
7001 a Cikes, Maja4 aut
7102 a Erasmus University Medical Centerb Catholic University of Louvain4 org
7730 t Heart and Vesselsd : Springer Science and Business Media LLCg 37:12, s. 1985-1994q 37:12<1985-1994x 0910-8327x 1615-2573
8564 u http://dx.doi.org/10.1007/s00380-022-02111-1y FULLTEXT
8564 8u https://lup.lub.lu.se/record/113bb48c-9634-4157-8f7d-d57b8a3b8997
8564 8u https://doi.org/10.1007/s00380-022-02111-1
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:150014361

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