id:"swepub:oai:lup.lub.lu.se:12bb1ef4-7dec-4020-ad86-b436f3fbd429"
Search: id:"swepub:oai:lup.lub.lu.se:12bb1ef4-7dec-4020-ad86-b436f3fbd429" > Detectability of ne...
- 1 of 1
- Previous record
- Next record
- To hitlist
Detectability of new psychoactive substances, 'legal highs', in CEDIA, EMIT, and KIMS immunochemical screening assays for drugs of abuse
-
- Beck, Olof (author)
- Karolinska Institutet
- Rausberg, Linnea (author)
- Al-Saffar, Yasir (author)
- show more...
- Villen, Tomas (author)
- Karlsson, Lennart (author)
- show less...
- (creator_code:org_t)
- 2014-03-24
- 2014
- English.
- In: Drug Testing and Analysis. - : Wiley. - 1942-7611 .- 1942-7603. ; 6:5, s. 492-499
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The increasing number of new psychoactive substances made available for recreational drug use has created a challenge for clinical toxicology and drug testing laboratories. As a consequence, the routine immunoassay drug testing may become less effective due to an increased occurrence of false negative and false positive screening results. This work aimed to extend the knowledge about analytical cross-reactivity of new substances in selected CEDIA, EMIT, and KIMS immunoassays for drugs-of-abuse screening. Urine standards were prepared by spiking blank urine with 45 new substances. Authentic urine samples from intoxication cases identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) were also studied. Several new psychoactive substances were demonstrated to display cross-reactivity in the immunoassays. CEDIA Amphetamine/Ecstasy and EMIT d.a.u. Amphetamine Class tests showed the highest reactivity towards the new drugs, which was expected since many have amphetamine-like structure and activity. In the samples from authentic cases, five new substances displayed 100% detection rate in the CEDIA Amphetamine/Ecstasy test. In conclusion, cross-reactivity data in routine urine drug screening immunoassays for a number of new psychoactive substances not studied before were reported. In both spiked and authentic urine samples, some new substances showed significant cross-reactivity and are thus detectable in the routine screening methods. Copyright (c) 2014 John Wiley & Sons, Ltd.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- CEDIA
- EMIT
- KIMS
- immunoassay
- urine
- drug testing
- new psychoactive
- substances
- drug screening
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Drug Testing and Analysis (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Beck, Olof
- Rausberg, Linnea
- Al-Saffar, Yasir
- Villen, Tomas
- Karlsson, Lennar ...
- Hansson, Therese
- show more...
- Helander, Anders
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Pharmaceutical S ...
- Articles in the publication
- Drug Testing and ...
- By the university
- Lund University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
