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Development of Huma...
Development of Humanized Ossicles : Bridging the Hematopoietic Gap
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- Dupard, Steven J. (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,WCMM- Wallenberg center för molekylär medicinsk forskning,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,WCMM-Wallenberg Centre for Molecular Medicine
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- Grigoryan, Ani (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,WCMM- Wallenberg center för molekylär medicinsk forskning,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,WCMM-Wallenberg Centre for Molecular Medicine
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- Farhat, Stephanie (författare)
- University of Ottawa,Ottawa Hospital Research Institute,The Ottawa Hospital
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- Coutu, Daniel L. (författare)
- The Ottawa Hospital,University of Ottawa,Ottawa Hospital Research Institute
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- Bourgine, Paul E. (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,WCMM- Wallenberg center för molekylär medicinsk forskning,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,WCMM-Wallenberg Centre for Molecular Medicine
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska 18 s.
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Ingår i: Trends in Molecular Medicine. - : Elsevier BV. - 1471-4914. ; 26:6, s. 552-569
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Ectopic 'humanized ossicles' (hOss) are miniaturized, engineered human bone organs in mice displaying a similar structure and function to native mouse bones. However, they are composed of human mesenchymal derived cells forming a humanized bone marrow niche. This in vivo reconstitution of human skeletal and hematopoietic compartments provides an opportunity to investigate the cellular and molecular processes involved in their establishment and functions in a human setting. However, current hOs strategies vary in their engineering methods and their downstream applications, undermining comprehensive exploitation of their potential. This review describes the specificities of the hOs models and highlights their potential and limits. Ultimately, we propose directions for the development of hOss as a technological platform for human hematopoietic studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- bone marrow niche
- bone tissue engineering
- hematopoiesis
- hematopoietic stem cells
- humanized ossicle
- mesenchymal stromal cells
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
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