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Homocystein--markör...
Homocystein--markör för kärlsjukdom hos aldre med psykisk sjukdom.
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- Hultberg, Björn (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Nilsson, Anna-Karin (författare)
- Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine
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Gustafson, Lars (författare)
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(creator_code:org_t)
- 2008
- 2008
- Svenska.
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Ingår i: Läkartidningen. - 0023-7205. ; 105:38, s. 2576-2578
- Relaterad länk:
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http://ltarkiv.lakar... (free)
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Abstract
Ämnesord
Stäng
- Many studies have reported higher total plasma homocysteine (tHcy) in elderly patients with mental illness than in control subjects. There are many different determinants of plasma tHcy concentration, including age, cobalamin/folate status, renal function and the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. We have investigated elderly patients with regard to plasma tHcy and the presence of vascular disease. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors such as age and genetics. The main findings in our studies imply that elevated plasma tHcy concentration in elderly patients with mental illness is mainly associated with the presence of vascular disease and is not related to the specific psychogeriatric diagnosis. Furthermore, it seems possible that the control of conventional vascular risk factors could be guided by the level of plasma tHcy, serum cystatin C, and serum N-terminal pro-brain natriuretic peptide. Patients with an elevation of any of these parameters could be selected for a lower target level of vascular risk factors such as blood pressure cholesterol etc. than conventional target levels.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Cognition Disorders: blood
- Cognition Disorders: complications
- Homocysteine: blood
- Mental Disorders: blood
- Vascular Diseases: etiology
- Mental Disorders: complications
- Vascular Diseases: blood
- Biological Markers: blood
- Alzheimer Disease: blood
- Alzheimer Disease: complications
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
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