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Hybrid Theranostic ...
Hybrid Theranostic Cubosomes for Efficient NIR-Induced Photodynamic Therapy
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- Bazylińska, Urszula (författare)
- Wrocław University of Science and Technology
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- Wawrzyńczyk, Dominika (författare)
- Wrocław University of Science and Technology
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- Kulbacka, Julita (författare)
- Wrocław Medical University
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- Picci, Giacomo (författare)
- University of Cagliari
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- Manni, Livia Salvati (författare)
- ETH Zürich
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- Handschin, Stephan (författare)
- ETH Zürich
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- Fornasier, Marco (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,University of Cagliari
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- Caltagirone, Claudia (författare)
- University of Cagliari
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- Mezzenga, Raffaele (författare)
- ETH Zürich
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- Murgia, Sergio (författare)
- University of Cagliari
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(creator_code:org_t)
- 2022-03-25
- 2022
- Engelska 12 s.
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Ingår i: ACS Nano. - : American Chemical Society (ACS). - 1936-0851 .- 1936-086X. ; 16:4, s. 5427-5438
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In recent years, lipid bicontinuous cubic liquid-crystalline nanoparticles known as cubosomes have been under investigation because of their favorable properties as drug nanocarriers useful for anticancer treatments. Herein, we present organic/inorganic hybrid, theranostic cubosomes stabilized in water with a shell of alternate layers of chitosan, single strand DNA (model genetic material for potential gene therapy), and folic acid-chitosan conjugate (the outmost layer), coencapsulating up-converting Er3+ and Yb3+ codoped NaYF4 nanoparticles and daunorubicin. The latter acts as a chemotherapeutic drug of photosensitizing activity, while up-converting nanoparticles serve as energy harvester and diagnostic agent. Cellular uptake and NIR-induced photodynamic therapy were evaluated in vitro against human skin melanoma (MeWo) and ovarian (SKOV-3) cancer cells. Results evidenced the preferential uptake of the theranostic cubosomes in SKOV-3 cells in comparison to uptake in MeWo cells, and this effect was enhanced by the folic acid functionalization of the cubosomes surface. Nanocarriers coloaded with the hybrid fluorophores exhibited a superior NIR-induced photodynamic activity, also confirmed by the improved mitochondrial activity and the most affecting f-actin fibers of cytoskeleton. Similar results, but with higher photocytotoxicity, were detected when folic acid-functionalized cubosomes were incubated with SKOV-3 cells. Taken on the whole, these results prove these hybrid cubosomes are good candidates for the photodynamic treatment of tumor lesions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- antitumor activity
- daunorubicin
- layer-by-layer
- lipid bicontinuous cubic liquid-crystalline nanoparticles
- MeWo cells
- SKOV-3 cells
- up-converting nanocrystals
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ACS Nano
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- Av författaren/redakt...
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Bazylińska, Ursz ...
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Wawrzyńczyk, Dom ...
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Kulbacka, Julita
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Picci, Giacomo
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Manni, Livia Sal ...
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Handschin, Steph ...
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visa fler...
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Fornasier, Marco
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Caltagirone, Cla ...
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Mezzenga, Raffae ...
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Murgia, Sergio
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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ACS Nano
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