id:"swepub:oai:lup.lub.lu.se:1f805c89-6969-4db8-80c2-c482393736a0"
Search: id:"swepub:oai:lup.lub.lu.se:1f805c89-6969-4db8-80c2-c482393736a0" > Risk factors for ca...
- 1 of 1
- Previous record
- Next record
- To hitlist
Risk factors for cardiovascular malformation - a study based on prospectively collected data
-
- Cedergren, Marie, 1963- (author)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
-
- Selbing, Anders, 1946- (author)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
-
- Källén, Bengt (author)
- Lund University,Lunds universitet,Tornbladinstitutet,Forskargrupper vid Lunds universitet,Tornblad Institute,Lund University Research Groups,Tornblad Institute, University of Lund, Lund, Sweden
- (creator_code:org_t)
- Scandinavian Journal of Work, Environment and Health, 2002
- 2002
- English.
- In: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 28:1, s. 12-17
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Objectives The aim of this study was to identify risk factors for cardiovascular malformation. Methods In a case-referent study prospectively collected data were obtained from original medical records. The study included 277 woman who had infants with a severe cardiac defect, and for each case two referents (medical records study) were included. Data on parental age, maternal reproductive history, disease in early pregnancy, reported maternal use of drugs and alcohol, smoking habits, parental occupation, and maternal body mass index (BMI) were extracted. When data were available from Swedish medical health registers, a comparison was made (register study) between all infants with cardiovascular defects (2208) and all infants born (175 768). Results Maternal diabetes mellitus was associated with an increased risk for cardiovascular malformation [odds ratio (OR) 2.38, 95% confidence interval (95% CI) 1.36-4.15], as was a high BMI (> 29) (OR 1.46, 95%CI 1.12-1.90). A tendency towards an increased risk was found for involuntary childlessness, spontaneous abortion, thyroid drugs, and nonsteroid anti-inflammatory drugs. Conclusions Some known risk factors for cardiac defects (eg, maternal diabetes mellitus and the use of antiepileptics) could be identified. Other postulated risk factors could not be verified, for example, paternal age and parental occupation. The use of medicinal drugs seems not to be a major factor in the etiology of cardiac defects. It is possible, however, that there is an association with the use of nonsteroid anti-inflammatory drugs or drugs for thyroid disease. The relationship between a high BMI and cardiovascular malformation observed in this study may be explained by impaired maternal glucose tolerance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- prospective study
- parental age
- drugs
- body mass index
- cardiac defect
- MEDICINE
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Scandinavian Journal of Work, Environment and Health (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Cedergren, Marie ...
- Selbing, Anders, ...
- Källén, Bengt
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Health Sciences
- and Occupational Hea ...
- Articles in the publication
- Scandinavian Jou ...
- By the university
- Lund University
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
