id:"swepub:oai:lup.lub.lu.se:28183fe6-a550-4f8d-aa66-2b3d267fc60e"
Search: id:"swepub:oai:lup.lub.lu.se:28183fe6-a550-4f8d-aa66-2b3d267fc60e" > Copy Number Defects...
- 1 of 1
- Previous record
- Next record
- To hitlist
Copy Number Defects of G1-Cell Cycle Genes in Neuroblastoma are Frequent and Correlate with High Expression of E2F Target Genes and a Poor Prognosis
- Molenaar, Jan J. (author)
- Koster, Jan (author)
- Ebus, Marli E. (author)
- show more...
- van Sluis, Peter (author)
- Westerhout, Ellen M. (author)
- de Preter, Katleen (author)
- Speleman, Frank (author)
- Caron, Huib N. (author)
- Versteeg, Rogier (author)
- show less...
- (creator_code:org_t)
- 2011-10-27
- 2012
- English.
- In: Genes, Chromosomes and Cancer. - : Wiley. - 1045-2257. ; 51:1, s. 10-19
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The tightly controlled network of cell cycle genes consists of a core of cyclin dependent kinases (CDKs) that are activated by periodically expressed cyclins. The activity of the cyclin-CDK complexes is regulated by cyclin dependent kinase inhibitors (CDKIs) and multiple signal transduction routes that converge on the cell cycle. Neuroblastoma are pediatric tumors that belong to the group of small round blue cell tumors, characterized by a fast proliferation. Here, we present high throughput analyses of cell cycle regulating genes in neuroblastoma. We analyzed a series of 82 neuroblastomas by comparative genomic hybridization arrays, single nucleotide polymorphism arrays, and Affymetrix expression arrays and analyzed the datasets in parallel with the R2 bioinformatic tool (http://r2.amc.nl). About 30% of the tumors had genomic amplifications, gains, or losses with shortest regions of overlap that suggested implication of a series of G1 cell cycle regulating genes. CCND1 (cyclin D1) and CDK4 were amplified or gained and the chromosomal regions containing the CDKN2 (INK4) group of CDKIs were frequently deleted. Cluster analysis showed that tumors with genomic aberrations in G1 regulating genes over-expressed E2F target genes, which regulate S and G2/M phase progression. These tumors have a poor prognosis. Our findings suggest that pharmacological inhibition of cell cycle genes might bear therapeutic promises for patients with high risk neuroblastoma. (C) 2011 Wiley Periodicals, Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Genes, Chromosomes and Cancer (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Molenaar, Jan J.
- Koster, Jan
- Ebus, Marli E.
- van Sluis, Peter
- Westerhout, Elle ...
- de Preter, Katle ...
- show more...
- Gisselsson Nord, ...
- Øra, Ingrid
- Speleman, Frank
- Caron, Huib N.
- Versteeg, Rogier
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- Genes, Chromosom ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
