Search: id:"swepub:oai:lup.lub.lu.se:2ae4db3b-b59d-4e03-becb-43214eb0229d" >
Safety, immunogenic...
Safety, immunogenicity, pharmacokinetics, and efficacy of degradation of anti-HLA antibodies by IdeS (imlifidase) in chronic kidney disease patients
-
- Lorant, Tomas, 1975- (author)
- Uppsala universitet,Uppsala University,Transplantationskirurgi
-
- Bengtsson, Mats (author)
- Uppsala universitet,Uppsala University,Klinisk immunologi
-
- Eich, Torsten, 1972- (author)
- Uppsala universitet,Uppsala University,Klinisk immunologi
-
show more...
-
- Eriksson, Britt-Marie, Docent, 1952- (author)
- Uppsala universitet,Uppsala University,Infektionssjukdomar
-
- Winstedt, Lena (author)
- Hansa Medical AB, Lund, Sweden
-
- Järnum, Sofia (author)
- Hansa Medical AB, Lund, Sweden
-
- Stenberg, Yvonne (author)
- Hansa Medical AB, Lund, Sweden
-
- Robertson, Anna Karin (author)
- Hansa Medical AB, Lund, Sweden
-
- Mosén, Kristina (author)
- Hansa Medical AB, Lund, Sweden
-
- Björck, Lars (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
-
- Bäckman, Lars (author)
- Uppsala universitet,Uppsala University,Transplantationskirurgi
-
- Larsson, Erik (author)
- Uppsala universitet,Uppsala University,Klinisk och experimentell patologi
-
- Wood, Kathryn (author)
- Nuffield Department of Surgical Sciences, Oxford University, Oxford, UK
-
- Tufveson, Gunnar (author)
- Uppsala universitet,Uppsala University,Transplantationskirurgi
-
- Kjellman, Christian (author)
- Hansa Medical AB, Lund, Sweden
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
-
In: American Journal of Transplantation. - : Elsevier BV. - 1600-6135 .- 1600-6143. ; 18:11, s. 2752-2762
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://onlinelibrar...
-
https://doi.org/10.1...
-
https://uu.diva-port... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Safety, immunogenicity, pharmacokinetics, and efficacy of the IgG-degrading enzyme of Streptococcus pyogenes (IdeS [imlifidase]) were assessed in a single-center, open-label ascending-dose study in highly sensitized patients with chronic kidney disease. Eight patients with cytotoxic PRAs (median cytotoxic PRAs of 64%) at enrollment received 1 or 2 intravenous infusions of IdeS on consecutive days (0.12 mg/kg body weight ×2 [n = 3]; 0.25 mg/kg ×1 [n = 3], or 0.25 mg/kg ×2 [n = 2]). IgG degradation was observed in all subjects after IdeS treatment, with <1% plasma IgG remaining within 48 hours and remaining low up to 7 days. Mean fluorescence intensity values of HLA class I and II reactivity were substantially reduced in all patients, and C1q binding to anti-HLA was abolished. IdeS also cleaved the IgG-type B cell receptor on CD19+ memory B cells. Anti-IdeS antibodies developed 1 week after treatment, peaking at 2 weeks. A few hours after the second IdeS infusion, 1 patient received a deceased donor kidney offer. At enrollment, the patient had a positive serum crossmatch (HLA-B7), detected by complement-dependent cytotoxicity, flow cytometry, and multiplex bead assays. After IdeS infusion (0.12 mg/kg ×2) and when the HLA-incompatible donor (HLA-B7+) kidney was offered, the HLA antibody profile was negative. The kidney was transplanted successfully.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Clinical research/practice
- Clinical trial
- Crossmatch
- Desensitization
- Histocompatibility
- Kidney transplantation/nephrology
- Kidney transplantation: living donor
- Pharmacokinetics/pharmacodynamics
- clinical research/practice
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lorant, Tomas, 1 ...
-
Bengtsson, Mats
-
Eich, Torsten, 1 ...
-
Eriksson, Britt- ...
-
Winstedt, Lena
-
Järnum, Sofia
-
show more...
-
Stenberg, Yvonne
-
Robertson, Anna ...
-
Mosén, Kristina
-
Björck, Lars
-
Bäckman, Lars
-
Larsson, Erik
-
Wood, Kathryn
-
Tufveson, Gunnar
-
Kjellman, Christ ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Urology and Neph ...
- Articles in the publication
-
American Journal ...
- By the university
-
Lund University
-
Uppsala University