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Sökning: id:"swepub:oai:lup.lub.lu.se:2d3a29ba-59b1-46b5-9fc2-8fac9fef9def" > Orthostatic hypoten...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005249naa a2200577 4500
001oai:lup.lub.lu.se:2d3a29ba-59b1-46b5-9fc2-8fac9fef9def
003SwePub
008160404s2012 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/25193912 URI
0247 a https://doi.org/10.1093/eurheartj/ehs0582 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Fedorowski, Arturu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)med-afr
2451 0a Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.
264 c 2012-04-14
264 1b Oxford University Press (OUP),c 2012
520 a Aims: Orthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure (BP) in populations, but their impact on OH remains unknown.Methods and resultsA total of 38 970 men and women of European ancestry from five population-based cohorts were included, of whom 2656 (6.8%) met the diagnostic criteria for OH (systolic/diastolic BP drop ≥20/10 mmHg within 3 min of standing). Thirty-one recently discovered BP-associated single nucleotide polymorphisms (SNPs) were examined using an additive genetic model and the major allele as referent. Relations between OH, orthostatic systolic BP response, and genetic variants were assessed by inverse variance-weighted meta-analysis. We found Bonferroni adjusted (P < 0.0016) significant evidence for association between OH and the EBF1 locus (rs11953630, per-minor-allele odds ratio, 95% confidence interval: 0.90, 0.85-0.96; P = 0.001), and nominal evidence (P < 0.05) for CYP17A1 (rs11191548: 0.85, 0.75-0.95; P = 0.005), and NPR3-C5orf23 (rs1173771: 0.92, 0.87-0.98; P= 0.009) loci. Among subjects not taking BP-lowering drugs, three SNPs within the NPPA/NPPB locus were nominally associated with increased risk of OH (rs17367504: 1.13, 1.02-1.24; P = 0.02, rs198358: 1.10, 1.01-1.20; P = 0.04, and rs5068: 1.22, 1.04-1.43; P = 0.01). Moreover, an ADM variant was nominally associated with continuous orthostatic systolic BP response in the adjusted model (P= 0.04).ConclusionThe overall association between common gene variants in BP loci and OH was generally weak and the direction of effect inconsistent with resting BP findings. These results suggest that OH and resting BP share few genetic components.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Franceschini, Nora4 aut
7001 a Brody, Jennifer4 aut
7001 a Liu, Chunyu4 aut
7001 a Verwoert, Germaine C4 aut
7001 a Boerwinkle, Eric4 aut
7001 a Couper, David4 aut
7001 a Rice, Kenneth M4 aut
7001 a Rotter, Jerome I4 aut
7001 a Raso, Francesco Mattace4 aut
7001 a Uitterlinden, Andre4 aut
7001 a Hofman, Albert4 aut
7001 a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal
7001 a Sjögren, Marketau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Cardiovascular Research - Hypertension4 aut0 (Swepub:lu)endo-msj
7001 a Hedblad, Bou Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-bhe
7001 a Larson, Martin G4 aut
7001 a Newton-Cheh, Christopher4 aut
7001 a Wang, Thomas J4 aut
7001 a Rose, Kathryn M4 aut
7001 a Psaty, Bruce M4 aut
7001 a Levy, Daniel4 aut
7001 a Witteman, Jacqueline4 aut
7001 a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
7102 a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org
7730 t European Heart Journald : Oxford University Press (OUP)g 33:18, s. 2331-2341q 33:18<2331-2341x 1522-9645x 0195-668X
8564 u http://www.ncbi.nlm.nih.gov/pubmed/22504314?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1093/eurheartj/ehs058y FULLTEXT
8564 u https://academic.oup.com/eurheartj/article-pdf/33/18/2331/17050280/ehs058.pdf
8564 8u https://lup.lub.lu.se/record/2519391
8564 8u https://doi.org/10.1093/eurheartj/ehs058

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