Sökning: id:"swepub:oai:lup.lub.lu.se:2d3a29ba-59b1-46b5-9fc2-8fac9fef9def" > Orthostatic hypoten...
Fältnamn | Indikatorer | Metadata |
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000 | 05249naa a2200577 4500 | |
001 | oai:lup.lub.lu.se:2d3a29ba-59b1-46b5-9fc2-8fac9fef9def | |
003 | SwePub | |
008 | 160404s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/25193912 URI |
024 | 7 | a https://doi.org/10.1093/eurheartj/ehs0582 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Fedorowski, Arturu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)med-afr |
245 | 1 0 | a Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium. |
264 | c 2012-04-14 | |
264 | 1 | b Oxford University Press (OUP),c 2012 |
520 | a Aims: Orthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure (BP) in populations, but their impact on OH remains unknown.Methods and resultsA total of 38 970 men and women of European ancestry from five population-based cohorts were included, of whom 2656 (6.8%) met the diagnostic criteria for OH (systolic/diastolic BP drop ≥20/10 mmHg within 3 min of standing). Thirty-one recently discovered BP-associated single nucleotide polymorphisms (SNPs) were examined using an additive genetic model and the major allele as referent. Relations between OH, orthostatic systolic BP response, and genetic variants were assessed by inverse variance-weighted meta-analysis. We found Bonferroni adjusted (P < 0.0016) significant evidence for association between OH and the EBF1 locus (rs11953630, per-minor-allele odds ratio, 95% confidence interval: 0.90, 0.85-0.96; P = 0.001), and nominal evidence (P < 0.05) for CYP17A1 (rs11191548: 0.85, 0.75-0.95; P = 0.005), and NPR3-C5orf23 (rs1173771: 0.92, 0.87-0.98; P= 0.009) loci. Among subjects not taking BP-lowering drugs, three SNPs within the NPPA/NPPB locus were nominally associated with increased risk of OH (rs17367504: 1.13, 1.02-1.24; P = 0.02, rs198358: 1.10, 1.01-1.20; P = 0.04, and rs5068: 1.22, 1.04-1.43; P = 0.01). Moreover, an ADM variant was nominally associated with continuous orthostatic systolic BP response in the adjusted model (P= 0.04).ConclusionThe overall association between common gene variants in BP loci and OH was generally weak and the direction of effect inconsistent with resting BP findings. These results suggest that OH and resting BP share few genetic components. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Franceschini, Nora4 aut |
700 | 1 | a Brody, Jennifer4 aut |
700 | 1 | a Liu, Chunyu4 aut |
700 | 1 | a Verwoert, Germaine C4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Couper, David4 aut |
700 | 1 | a Rice, Kenneth M4 aut |
700 | 1 | a Rotter, Jerome I4 aut |
700 | 1 | a Raso, Francesco Mattace4 aut |
700 | 1 | a Uitterlinden, Andre4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal |
700 | 1 | a Sjögren, Marketau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Cardiovascular Research - Hypertension4 aut0 (Swepub:lu)endo-msj |
700 | 1 | a Hedblad, Bou Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-bhe |
700 | 1 | a Larson, Martin G4 aut |
700 | 1 | a Newton-Cheh, Christopher4 aut |
700 | 1 | a Wang, Thomas J4 aut |
700 | 1 | a Rose, Kathryn M4 aut |
700 | 1 | a Psaty, Bruce M4 aut |
700 | 1 | a Levy, Daniel4 aut |
700 | 1 | a Witteman, Jacqueline4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
710 | 2 | a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t European Heart Journald : Oxford University Press (OUP)g 33:18, s. 2331-2341q 33:18<2331-2341x 1522-9645x 0195-668X |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/22504314?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1093/eurheartj/ehs058y FULLTEXT |
856 | 4 | u https://academic.oup.com/eurheartj/article-pdf/33/18/2331/17050280/ehs058.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/2519391 |
856 | 4 8 | u https://doi.org/10.1093/eurheartj/ehs058 |
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