id:"swepub:oai:lup.lub.lu.se:2d9703f6-a4f1-489a-8cd1-6dc3a7b9b3ac"
Search: id:"swepub:oai:lup.lub.lu.se:2d9703f6-a4f1-489a-8cd1-6dc3a7b9b3ac" > Protein Kinase C-γ ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Protein Kinase C-γ and Calcium/Calmodulin-Dependent Protein Kinase II-α Are Persistently Translocated to Cell Membranes of the Rat Brain during and after Middle Cerebral Artery Occlusion
-
- Matsumoto, Shohei (author)
- Skåne University Hospital,Tokyo Medical University
- Shamloo, Mehrdad (author)
-
- Matsumoto, Eriko (author)
- Tokyo Medical University,Skåne University Hospital
- show more...
- show less...
- (creator_code:org_t)
- 2004
- 2004
- English 8 s.
- In: Journal of Cerebral Blood Flow and Metabolism. - 0271-678X .- 1559-7016. ; 24:1, s. 54-61
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The levels of protein kinase C-γ (PKC-γ) and the calcium/calmodulin-dependent kinase II-α (CaMKII-α) were measured in crude synaptosomal (P2), particulate (P3), and cytosolic (S3) fractions of the neocortex of rats exposed to 1-hour and 2-hour middle cerebral artery occlusion (MCAO) and 2-hour MCAO followed by 2-hour reperfusion. During MCAO, PKC levels increased in P2 and P3 in the most severe ischemic areas concomitantly with a decrease in S3. In the penumbra, PKCγ decreased in S3 without any significant increases in P2 and P3. Total PKC-γ also decreased in the penumbra but not in the ischemic core, suggesting that the protein is degraded by an energy-dependent mechanism, possibly by the 26S proteasome. The CaMKII-α levels increased in P2 but not P3 during ischemia and reperfusion in all ischemic regions, particularly in the ischemic core. Concomitantly, the levels in S3 decreased by 20% to 40% in the penumbra and by approximately 80% in the ischemic core. There were no changes in the total levels of CaMKII-α during MCAO. The authors conclude that during and after ischemia, PKC and CaMKII-α are translocated to the cell membranes, particularly synaptic membranes, where they may modulate cellular function, such as neurotransmission, and also affect cell survival. Drugs preventing PKC and/or CaMKII-α translocation may prove beneficial against ischemic cell death.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- CaMKII
- Cell death
- Protein kinase C
- Signal transduction
- Stroke
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Journal of Cerebral Blood Flow and Metabolism (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Matsumoto, Shohe ...
- Shamloo, Mehrdad
- Matsumoto, Eriko
- Isshiki, Atsushi
- Wieloch, Tadeusz
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Medical Biotechn ...
- and Medical Biotechn ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
- Articles in the publication
- Journal of Cereb ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
