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Monocyte depletion ...
Monocyte depletion early after stroke promotes neurogenesis from endogenous neural stem cells in adult brain
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- Laterza, Cecilia (author)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Wattananit, Somsak (author)
- Skåne University Hospital
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- Uoshima, Naomi (author)
- Lund University,Tokyo Medical University,Skåne University Hospital
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- Ge, Ruimin (author)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Pekny, Roy (author)
- Skåne University Hospital,Lund University
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- Tornero, Daniel (author)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Monni, Emanuela (author)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Lindvall, Olle (author)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Kokaia, Zaal (author)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English 9 s.
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In: Experimental Neurology. - : Elsevier BV. - 0014-4886. ; 297, s. 129-137
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Ischemic stroke, caused by middle cerebral artery occlusion, leads to long-lasting formation of new striatal neurons from neural stem/progenitor cells (NSPCs) in the subventricular zone (SVZ) of adult rodents. Concomitantly with this neurogenic response, SVZ exhibits activation of resident microglia and infiltrating monocytes. Here we show that depletion of circulating monocytes, using the anti-CCR2 antibody MC-21 during the first week after stroke, enhances striatal neurogenesis at one week post-insult, most likely by increasing short-term survival of the newly formed neuroblasts in the SVZ and adjacent striatum. Blocking monocyte recruitment did not alter the volume of the ischemic lesion but gave rise to reduced astrocyte activation in SVZ and adjacent striatum, which could contribute to the improved neuroblast survival. A similar decrease of astrocyte activation was found in and around human induced pluripotent stem cell (iPSC)-derived NSPCs transplanted into striatum at one week after stroke in monocyte-depleted mice. However, there was no effect on neurogenesis in the graft as determined 8 weeks after implantation. Our findings demonstrate, for the first time, that a specific cellular component of the early inflammatory reaction in SVZ and adjacent striatum following stroke, i.e., infiltrating monocytes, compromises the short-term neurogenic response neurogenesis from endogenous NSPCs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Monocyte depletion
- Neurogenesis
- Reactive gliosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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