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id:"swepub:oai:lup.lub.lu.se:301e11f0-736a-4781-a5b4-929c72a80017"
 

Sökning: id:"swepub:oai:lup.lub.lu.se:301e11f0-736a-4781-a5b4-929c72a80017" > Ring chromosomes, b...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003713naa a2200433 4500
001oai:lup.lub.lu.se:301e11f0-736a-4781-a5b4-929c72a80017
003SwePub
008160401s2015 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/48161882 URI
0247 a https://doi.org/10.1002/gcc.222282 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Macchia, Gemma4 aut
2451 0a Ring chromosomes, breakpoint clusters, and neocentromeres in sarcomas.
264 c 2014-11-25
264 1b Wiley,c 2015
520 a Gene amplification is relatively common in tumors. In certain subtypes of sarcoma, it often occurs in the form of ring and/or giant rod-shaped marker (RGM) chromosomes whose mitotic stability is frequently rescued by ectopic novel centromeres (neocentromeres). Little is known about the origin and structure of these RGM chromosomes, including how they arise, their internal organization, and which sequences underlie the neocentromeres. To address these questions, 42 sarcomas with RGM chromosomes were investigated to detect regions prone to double strand breaks and possible functional or structural constraints driving the amplification process. We found nine breakpoint cluster regions potentially involved in the genesis of RGM chromosomes, which turned out to be significantly enriched in poly-pyrimidine traits. Some of the clusters were located close to genes already known to be relevant for sarcomas, thus indicating a potential functional constraint, while others mapped to transcriptionally inactive chromatin domains enriched in heterochromatic sites. Of note, five neocentromeres were identified after analyzing 13 of the cases by fluorescent in situ hybridization. ChIP-on-chip analysis with antibodies against the centromeric protein CENP-A showed that they were a patchwork of small genomic segments derived from different chromosomes, likely joint to form a contiguous sequence during the amplification process. © 2014 Wiley Periodicals, Inc.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Hansén Nord, Karolinu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)klin-kha
7001 a Zoli, Monica4 aut
7001 a Purgato, Stefania4 aut
7001 a D'Addabbo, Pietro4 aut
7001 a Whelan, Christopher W4 aut
7001 a Carbone, Lucia4 aut
7001 a Perini, Giovanni4 aut
7001 a Mertens, Fredriku Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-fme
7001 a Rocchi, Mariano4 aut
7001 a Storlazzi, Clelia Tiziana4 aut
7102 a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org
7730 t Genes, Chromosomes and Cancerd : Wileyg 54:3, s. 156-167q 54:3<156-167x 1045-2257
8564 u http://www.ncbi.nlm.nih.gov/pubmed/25421174?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1002/gcc.22228y FULLTEXT
8564 u http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2264
8564 8u https://lup.lub.lu.se/record/4816188
8564 8u https://doi.org/10.1002/gcc.22228

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