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The vermiform appen...
The vermiform appendix impacts the risk of developing Parkinson’s disease
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- Killinger, Bryan A. (author)
- Van Andel Research Institute
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- Madaj, Zachary (author)
- Van Andel Research Institute
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- Sikora, Jacek W. (author)
- Northwestern University
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- Rey, Nolwen (author)
- Van Andel Research Institute,Paris-Saclay Institute of Neuroscience
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- Haas, Alec J. (author)
- Van Andel Research Institute
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- Vepa, Yamini (author)
- Van Andel Research Institute
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- Lindqvist, Daniel (author)
- Lund University,Lunds universitet,Enheten för klinisk suicidforskning,Forskargrupper vid Lunds universitet,Unit for clinical suicide research,Lund University Research Groups,Skåne University Hospital
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- Chen, Honglei (author)
- Michigan State University
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- Thomas, Paul M. (author)
- Northwestern University
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- Brundin, Patrik (author)
- Van Andel Research Institute
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- Brundin, Lena (author)
- Van Andel Research Institute
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- Labrie, Viviane (author)
- Van Andel Research Institute,Centre for Addiction and Mental Health (CAMH)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2018
- 2018
- English.
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In: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 10:465
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Abstract
Subject headings
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- The pathogenesis of Parkinson’s disease (PD) involves the accumulation of aggregated -synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we determined the capacity of the appendix to modify PD risk and influence pathogenesis. In two independent epidemiological datasets, involving more than 1.6 million individuals and over 91 million person-years, we observed that removal of the appendix decades before PD onset was associated with a lower risk for PD, particularly for individuals living in rural areas, and delayed the age of PD onset. We also found that the healthy human appendix contained intraneuronal -synuclein aggregates and an abundance of PD pathology–associated -synuclein truncation products that are known to accumulate in Lewy bodies, the pathological hallmark of PD. Lysates of human appendix tissue induced the rapid cleavage and oligo-merization of full-length recombinant -synuclein. Together, we propose that the normal human appendix contains pathogenic forms of -synuclein that affect the risk of developing PD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Killinger, Bryan ...
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Madaj, Zachary
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Sikora, Jacek W.
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Rey, Nolwen
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Haas, Alec J.
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Vepa, Yamini
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show more...
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Lindqvist, Danie ...
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Chen, Honglei
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Thomas, Paul M.
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Brundin, Patrik
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Brundin, Lena
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Labrie, Viviane
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Science Translat ...
- By the university
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Lund University