id:"swepub:oai:lup.lub.lu.se:368429ad-296e-4338-82c7-da390e40abf5"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03131naa a2200385 4500 | |
| 001 | oai:lup.lub.lu.se:368429ad-296e-4338-82c7-da390e40abf5 | |
| 003 | SwePub | |
| 008 | 160401s2002 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/3435872 URI |
| 024 | 7 | a https://doi.org/10.1152/ajpendo.00261.20012 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Halloran, B4 aut |
| 245 | 1 0 | a Parathyroid gland volume increases with postmaturational aging in the rat |
| 264 | 1 | b American Physiological Society,c 2002 |
| 520 | a To examine the pathophysiology of the age-related rise in the plasma concentration of parathyroid hormone (PTH), we studied the relationships among plasma immunoreactive PTH (iPTH), parathyroid gland volume, parathyroid cell proliferation rate, renal function, and blood Ca2+ in male Fischer 344 rats aged 6-28 mo. Plasma iPTH increased 2.5-fold between 6 and 28 mo and correlated with parathyroid gland volume (r=0.87). Gland volume began to increase as early as 6-12 mo of age and by 28 mo was threefold greater than at 6 mo. Gland expansion was a consequence of hyperplasia stimulated in part by an increase in cell proliferative activity late in life. Blood Ca2+ and plasma inorganic phosphorus did not change significantly with age. Glomerular filtration rate decreased with age but only after the age of 24 mo. Unlike what has been observed in the human, these data suggest that the age-related increase in plasma iPTH in the rat is linked to parathyroid gland hyperplasia and that early gland growth does not appear to be associated with hypocalcemia or renal insufficiency, but rather to developmentally related metabolic changes. Later in life (>24 mo), the increase in parathyroid cell proliferation rate, further hyperplastic expansion of the gland, and increase in iPTH secretion appear to be associated with renal insufficiency. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
| 653 | a glomerular filtration rate | |
| 653 | a parathyroid hormone | |
| 653 | a renal function | |
| 700 | 1 | a Udén, Peru Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)extLU-314 |
| 700 | 1 | a Duh, QY4 aut |
| 700 | 1 | a Kikuchi, S4 aut |
| 700 | 1 | a Wieder, T4 aut |
| 700 | 1 | a Cao, J4 aut |
| 700 | 1 | a Clark, O4 aut |
| 710 | 2 | a Institutionen för kliniska vetenskaper, Malmöb Medicinska fakulteten4 org |
| 773 | 0 | t American Journal of Physiology: Endocrinology and Metabolismd : American Physiological Societyg 282:3, s. 557-563q 282:3<557-563x 1522-1555x 0193-1849 |
| 856 | 4 | u http://dx.doi.org/10.1152/ajpendo.00261.2001x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/343587 |
| 856 | 4 8 | u https://doi.org/10.1152/ajpendo.00261.2001 |
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