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The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1 + precursors.

Pærregaard, Simone Isling (author)
Technical University of Denmark
Wulff, Line (author)
Technical University of Denmark
Schussek, Sophie (author)
Technical University of Denmark
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Niss, Kristoffer (author)
University of Copenhagen
Mörbe, Urs (author)
Technical University of Denmark
Jendholm, Johan (author)
Technical University of Denmark
Wendland, Kerstin (author)
Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups
Andrusaite, Anna T (author)
University of Glasgow
Brulois, Kevin F (author)
Stanford University
Nibbs, Robert J B (author)
University of Glasgow
Sitnik, Katarzyna (author)
Technical University of Denmark
Mowat, Allan McI (author)
University of Glasgow
Butcher, Eugene C (author)
Stanford University
Brunak, Søren (author)
University of Copenhagen
Agace, William W (author)
Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups,Technical University of Denmark
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 (creator_code:org_t)
2023
2023
English.
In: Nature Communications. - 2041-1723. ; 14, s. 1-16
Related links:
http://dx.doi.org/10... (free)
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The intestinal lamina propria contains a diverse network of fibroblasts that provide key support functions to cells within their local environment. Despite this, our understanding of the diversity, location and ontogeny of fibroblasts within and along the length of the intestine remains incomplete. Here we show that the small and large intestinal lamina propria contain similar fibroblast subsets that locate in specific anatomical niches. Nevertheless, we find that the transcriptional profile of similar fibroblast subsets differs markedly between the small intestine and colon suggesting region specific functions. We perform in vivo transplantation and lineage-tracing experiments to demonstrate that adult intestinal fibroblast subsets, smooth muscle cells and pericytes derive from Gli1-expressing precursors present in embryonic day 12.5 intestine. Trajectory analysis of single cell RNA-seq datasets of E12.5 and adult mesenchymal cells suggest that adult smooth muscle cells and fibroblasts derive from distinct embryonic intermediates and that adult fibroblast subsets develop in a linear trajectory from CD81 + fibroblasts. Finally, we provide evidence that colonic subepithelial PDGFRα hi fibroblasts comprise several functionally distinct populations that originate from an Fgfr2-expressing fibroblast intermediate. Our results provide insights into intestinal stromal cell diversity, location, function, and ontogeny, with implications for intestinal development and homeostasis.

Subject headings

NATURVETENSKAP  -- Biologi -- Utvecklingsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Developmental Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

Colon
Fibroblasts/metabolism
Intestine, Large/anatomy & histology
Intestine, Small
Intestines/anatomy & histology
Zinc Finger Protein GLI1/genetics
Mesenchymal Stem Cells/metabolism

Publication and Content Type

art (subject category)
ref (subject category)

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