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- Wester Rosenlöf, LenaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups (author)
Chronicity of pristane-induced arthritis in rats is controlled by genes on chromosome 14
- Article/chapterEnglish2003
Publisher, publication year, extent ...
- 2003
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- LIBRIS-ID:oai:lup.lub.lu.se:36d21b18-6e02-452b-b9b8-92ea5229d88b
- https://lup.lub.lu.se/record/294468URI
- https://doi.org/10.1016/S0896-8411(03)00136-7DOI
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- Language:English
- Summary in:English
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Notes
- To, address; he possibility, that genes specifically control the chronic phase of arthritis we have isolated a congenic fragment from the resistant E3; rat cm the, susceptible DA rat background. The isolated fragment covers the Pia6 quantitative trait locus on chromosome 14, which previously has been identified to be linked to chronic pristane induced arthritis (PIA) in gene segregation experiments; of an (E3 x DA) F-2-cross. Heterozygous. Pia6 congenic rats (DA.Pia6) were protected from chronic active arthritis specifically, as determined by macroscopic scoring, histopathology and release of cartilage oligomeric matrix protein (-reflecting ongoing cartilage destruction). The difference was seen only during the chronic active phase of arthritis starting approximately 5 weeks after onset of arthritis. Interestingly, the plasma concentration of the lipocalins alpha(1)-acid glycoprotein and alpha(1)-microglobulin was found significantly altered in naive congenic rats compared to the DA rat. The concentration of alpha(1)-microglobulin was found to be significantly higher throughout the disease course, while alpha(1)-acid glycoprotein had a lower concentration in naive rats, which was highly significant in the chronic phase. The altered concentrations of these proteins already before development of chronic arthritis may provide a clue to the pathogenic process controlled by the Pia6 genes. We conclude that the active relapsing chronic arthritis is under a unique genetic control that is different from the control of acute arthritis and postulate that the liver plays an important role in this relagation. (C) 2003 Elsevier Ltd. All rights reserved..
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
- liver
- congenic animal
- cartilage oligomeric matrix protein
- alpha(1)-microglobulin
- alpha(1)-acid glycoprotein
Added entries (persons, corporate bodies, meetings, titles ...)
- Olofsson, PeterLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)infl-pol (author)
- Ibrahim, SM (author)
- Holmdahl, RikardLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)infl-rho (author)
- ImmunologiForskargrupper vid Lunds universitet (creator_code:org_t)
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- In:Journal of Autoimmunity21:4, s. 305-3130896-8411
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