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Needle biopsy throu...
Needle biopsy through the abdominal wall for the diagnosis of gastrointestinal stromal tumour - Does it increase the risk for tumour cell seeding and recurrence?
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- Eriksson, Mikael (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Reichardt, Peter (författare)
- HELIOS Klinikum Berlin-Buch
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- Sundby Hall, Kirsten (författare)
- Oslo university hospital
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- Schütte, Jochen (författare)
- Schwerpunktpraxis für Hämatologie, Onkologie & ambulante Tumortherapie – Krebs- und Blutheilkunde
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- Cameron, Silke (författare)
- University of Göttingen
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- Hohenberger, Peter (författare)
- University Medical Centre Mannheim
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- Bauer, Sebastian (författare)
- University of Duisburg-Essen
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- Leinonen, Mika (författare)
- 4Pharma Ltd
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- Reichardt, Annette (författare)
- HELIOS Klinikum Berlin-Buch
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- Rejmyr Davis, Maria (författare)
- Regional Cancer Center South, Lund
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- Alvegård, Thor (författare)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Joensuu, Heikki (författare)
- University of Helsinki
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska 6 s.
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 59, s. 128-133
- Relaterad länk:
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http://dx.doi.org/10...
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https://helda.helsin...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- PURPOSE: Preoperative percutaneous transabdominal wall biopsy may be considered to diagnose gastrointestinal stromal tumour (GIST) and plan preoperative treatment with tyrosine kinase inhibitors when an endoscopic biopsy is not possible. Hypothetically, a transabdominal wall biopsy might lead to cell seeding and conversion of a local GIST to a disseminated one. We investigated the influence of preoperative needle biopsy on survival outcomes.METHODS: We collected the clinical data from hospital case records of the 397 patients who participated in the Scandinavian Sarcoma Group (SSG) XVIII/Arbeitsgemeinschaft Internistische Onkologie (AIO) randomised trial and who had a transabdominal fine needle and/or core needle biopsy carried out prior to study entry. The SSG XVIII/AIO trial compared 1 and 3 years of adjuvant imatinib in a patient population with a high risk of GIST recurrence after macroscopically radical surgery. The primary end-point was recurrence-free survival (RFS), and the secondary end-points included overall survival (OS).RESULTS: A total of 47 (12.0%) out of the 393 patients with data available underwent a percutaneous biopsy. No significant difference in RFS or OS was found between the patients who underwent or did not undergo a percutaneous biopsy either in the entire series or in subpopulation analyses, except for a statistically significant RFS advantage for patients who had a percutaneous biopsy and a tumour ≥10 cm in diameter.CONCLUSION: A preoperative diagnostic percutaneous biopsy of a suspected GIST may not increase the risk for GIST recurrence in a patient population who receive adjuvant imatinib after the biopsy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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Eriksson, Mikael
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Reichardt, Peter
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Sundby Hall, Kir ...
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Schütte, Jochen
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Cameron, Silke
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Hohenberger, Pet ...
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visa fler...
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Bauer, Sebastian
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Leinonen, Mika
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Reichardt, Annet ...
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Rejmyr Davis, Ma ...
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Alvegård, Thor
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Joensuu, Heikki
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visa färre...
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