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Intestinal CART is ...
Intestinal CART is a regulator of GIP and GLP-1 secretion and expression
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- Shcherbina, L. (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups
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- Lindqvist, A. (author)
- Lund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups
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- Thorén Fischer, A. H. (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups
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- Ahlqvist, E. (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Zhang, E. (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups
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- Falkmer, S. E. (author)
- Ryhov County Hospital, Jönköping
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- Renström, E. (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups
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- Koffert, J. (author)
- Turku PET Centre
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- Honka, H. (author)
- Turku PET Centre
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- Wierup, N. (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Molecular and Cellular Endocrinology. - : Elsevier BV. - 0303-7207. ; 476, s. 8-16
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Impaired incretin effect is a culprit in Type 2 Diabetes. Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide controlling pancreatic islet hormone secretion and beta-cell survival. Here we studied the potential expression of CART in enteroendocrine cells and examined the role of CART as a regulator of incretin secretion and expression. CART expression was found in glucose-dependent insulinotropic polypeptide (GIP)-producing K-cells and glucagon-like peptide-1 (GLP-1)-producing L-cells in human duodenum and jejunum and circulating CART levels were increased 60 min after a meal in humans. CART expression was increased by fatty acids and GIP, but unaffected by glucose in GLUTag and STC-1 cells. Exogenous CART had no effect on GIP and GLP-1 expression and secretion in GLUTag or STC-1 cells, but siRNA-mediated silencing of CART reduced GLP-1 expression and secretion. Furthermore, acute intravenous administration of CART increased GIP and GLP-1 secretion during an oral glucose-tolerance test in mice. We conclude that CART is a novel constituent of human K- and L-cells with stimulatory actions on incretin secretion and that interfering with the CART system may be a therapeutic avenue for T2D.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- CART
- Cocaine- and amphetamine-regulated transcript
- Enteroendocrine cells
- GIP
- GLP-1
- Incretin hormones
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Shcherbina, L.
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Lindqvist, A.
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Thorén Fischer, ...
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Ahlqvist, E.
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Zhang, E.
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Falkmer, S. E.
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show more...
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Renström, E.
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Koffert, J.
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Honka, H.
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Wierup, N.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Molecular and Ce ...
- By the university
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Lund University