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Human fetal basal forebrain neurons grafted to the denervated rat hippocampus produce an organotypic cholinergic reinnervation pattern
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- Nilsson, O G (author)
- Lund University
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- Brundin, P (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Widner, H (author)
- Stockholm University
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- (creator_code:org_t)
- Elsevier BV, 1988
- 1988
- English 6 s.
- In: Brain Research. - : Elsevier BV. - 0006-8993. ; 456:1, s. 8-193
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The septal/diagonal band (SDB) area, obtained from a 9- to 10-week-old aborted human fetus, was grafted to the hippocampal formation of adult, immunosuppressed rats subjected to an aspirative lesion of the fimbria-fornix. Nineteen weeks after transplantation, microscopical analysis revealed large, partly acetylcholinesterase (AChE)-positive grafts in the hippocampus in 3 of the 5 recipients. The AChE-positive grafts gave rise to a reinnervation of the host hippocampus and an AChE-positive lamination of the different hippocampal subfields with the same characteristics as the normal septum-derived innervation. Immunological evaluation of host sera revealed that all rats were immunized by the graft. This indicates that grafted human cholinergic SDB neurons can respond to or interact with factors that regulate and guide the innervation of the rat hippocampus.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Acetylcholinesterase
- Animals
- Cholinergic Fibers
- Female
- Frontal Lobe
- Gestational Age
- Graft Survival
- Hippocampus
- Humans
- Neuronal Plasticity
- Rats
- Rats, Inbred Strains
- Transplantation, Heterologous
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
- Nilsson, O G
- Brundin, P
- Widner, H
- Strecker, R E
- Björklund, A
- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Brain Research
- By the university
- Lund University
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