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Rare cancers of unk...
Rare cancers of unknown etiology : lessons learned from a European multi-center case–control study
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- Lynge, Elsebeth (author)
- University of Copenhagen,Nykøbing Falster Hospital
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- Kaerlev, Linda (author)
- University of Southern Denmark,Odense University Hospital
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- Olsen, Jørn (author)
- Aarhus University Hospital
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- Sabroe, Svend (author)
- Aarhus University
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- Afonso, Noemia (author)
- Centro Hospitalar Universitário Porto
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- Ahrens, Wolfgang (author)
- University of Bremen,Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH
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- Eriksson, Mikael (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Merletti, Franco (author)
- University of Turin
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- Morales-Suarez-Varelas, Maria (author)
- University of Valencia,CIBER Epidemiology and Public Health (CIBERESP)
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- Stengrevics, Aivars (author)
- No affiliation available (private)
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- Guénel, Pascal (author)
- Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
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(creator_code:org_t)
- 2020-07-17
- 2020
- English 12 s.
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In: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 35:10, s. 937-948
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Abstract
Subject headings
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- Rare cancers together constitute one fourth of cancers. As some rare cancers are caused by occupational exposures, a systematic search for further associations might contribute to future prevention. We undertook a European, multi-center case–control study of occupational risks for cancers of small intestine, bone sarcoma, uveal melanoma, mycosis fungoides, thymus, male biliary tract and breast. Incident cases aged 35–69 years and sex-and age-matched population/colon cancer controls were interviewed, including a complete list of jobs. Associations between occupational exposure and cancer were assessed with unconditional logistic regression controlled for sex, age, country, and known confounders, and reported as odds ratios (OR) with 95% confidence intervals (CI). Interviewed were 1053 cases, 2062 population, and 1084 colon cancer controls. Male biliary tract cancer was associated with exposure to oils with polychlorinated biphenyls; OR 2.8 (95% CI 1.3–5.9); male breast cancer with exposure to trichloroethylene; OR 1.9 (95% CI 1.1–3.3); bone sarcoma with job as a carpenter/joiner; OR 4.3 (95% CI 1.7–10.5); and uveal melanoma with job as a welder/sheet metal worker; OR 1.95 (95% CI 1.08–3.52); and cook; OR 2.4 (95% CI 1.4–4.3). A confirmatory study of printers enhanced suspicion of 1,2-dichloropropane as a risk for biliary tract cancer. Results contributed to evidence for classification of welding and 1,2-dichloropronane as human carcinogens. However, despite efforts across nine countries, for some cancer sites only about 100 cases were interviewed. The Rare Cancer Study illustrated both the strengths and limitations of explorative studies for identification of etiological leads.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Cancer
- Risk factor
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lynge, Elsebeth
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Kaerlev, Linda
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Olsen, Jørn
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Sabroe, Svend
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Afonso, Noemia
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Ahrens, Wolfgang
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show more...
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Eriksson, Mikael
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Merletti, Franco
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Morales-Suarez-V ...
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Stengrevics, Aiv ...
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Guénel, Pascal
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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European Journal ...
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Lund University