id:"swepub:oai:lup.lub.lu.se:4b793ea3-1803-4da9-b492-ba4739042d68"
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Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20
- Ulvsbäck, M. (author)
- Lazure, C. (author)
-
- Lilja, Hans (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
- show more...
- Spurr, N. K. (author)
- Rao, V. V. (author)
- Loffler, C. (author)
- Hansmann, I. (author)
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- (creator_code:org_t)
- 1992
- 1992
- English.
- In: Journal of Biological Chemistry. - 0021-9258. ; 267:25, s. 4-18080
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The genes for semenogelin I and II, the major protein constituents of the human seminal fluid, have been characterized by three overlapping clones in bacteriophage lambda, encompassing 31.5 kilobases (kb) of genomic DNA. The two genes are located 11.5 kb apart in the region q12-q13.1 on chromosome 20. Both genes are relatively compact, spanning only 2.7 and 3.1 kb, respectively. The transcription units are composed of three exons, of which the first encodes the signal peptide, the second encodes the secreted protein, while the third solely contains 3'-noncoding nucleotides. The nucleotide sequences exhibit a similarity of close to 90% in the exons and exceeding 80% in the introns and flanking nucleotides.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- Molecular Sequence Data
- Male
- Humans
- Gonadal Steroid Hormones/*genetics
- DNA/genetics/isolation & purification
- Codon/genetics
- Molecular
- Cloning
- Pair 20
- Human
- *Chromosomes
- Chromosome Mapping
- Chromosome Banding
- Southern
- Blotting
- Amino Acid Sequence
- Base Sequence
- *Multigene Family
- Oligodeoxyribonucleotides
- Research Support
- Non-U.S. Gov't
- Restriction Mapping
- Semen/*physiology
- *Seminal Vesicle Secretory Proteins
- Spermatozoa/*physiology
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Ulvsbäck, M.
- Lazure, C.
- Lilja, Hans
- Spurr, N. K.
- Rao, V. V.
- Loffler, C.
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- Hansmann, I.
- Lundwall, Åke
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- Lund University
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