SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:lup.lub.lu.se:500b1e69-ddff-4e31-a216-89678fa416cc"
 

Search: id:"swepub:oai:lup.lub.lu.se:500b1e69-ddff-4e31-a216-89678fa416cc" > Escape from nonsens...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

Litchfield, Kevin (author)
Francis Crick Institute,University College London
Reading, James L. (author)
University College London
Lim, Emilia L. (author)
Francis Crick Institute
show more...
Xu, Hang (author)
Francis Crick Institute
Liu, Po (author)
Francis Crick Institute
Al-Bakir, Maise (author)
Francis Crick Institute
Wong, Yien Ning Sophia (author)
University College London
Rowan, Andrew (author)
Francis Crick Institute
Funt, Samuel A. (author)
Cornell University
Merghoub, Taha (author)
Cornell University
Perkins, David (author)
Francis Crick Institute
Lauss, Martin (author)
Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
Svane, Inge Marie (author)
Herlev Hospital
Jönsson, Göran (author)
Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
Herrero, Javier (author)
University College London
Larkin, James (author)
Royal Marsden Hospital, London
Quezada, Sergio A. (author)
University College London
Hellmann, Matthew D. (author)
Memorial Sloan-Kettering Cancer Center,Cornell University
Turajlic, Samra (author)
Royal Marsden Hospital, London,Francis Crick Institute
Swanton, Charles (author)
University College London,Francis Crick Institute
show less...
 (creator_code:org_t)
2020-07-30
2020
English.
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
Related links:
http://dx.doi.org/10... (free)
show more...
https://www.nature.c...
https://lup.lub.lu.s...
https://doi.org/10.1...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune responses. Using allele-specific expression analysis, expressed fs-indels are enriched in genomic positions predicted to escape NMD, and associated with higher protein expression, consistent with degradation escape (NMD-escape). Across four independent melanoma cohorts, NMD-escape mutations are significantly associated with clinical-benefit to checkpoint inhibitor (CPI) therapy (Pmeta = 0.0039). NMD-escape mutations are additionally found to associate with clinical-benefit in the low-TMB setting. Furthermore, in an adoptive cell therapy treated melanoma cohort, NMD-escape mutation count is the most significant biomarker associated with clinical-benefit. Analysis of functional T cell reactivity screens from personalized vaccine studies shows direct evidence of fs-indel derived neoantigens eliciting immune response, particularly those with highly elongated neo open reading frames. NMD-escape fs-indels represent an attractive target for biomarker optimisation and immunotherapy design.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view