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Sökning: WFRF:(Derendorf Hartmut) > (2010-2014) > Protein Binding :

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002531naa a2200349 4500
001oai:DiVA.org:uu-156025
003SwePub
008110706s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1560252 URI
0247 a https://doi.org/10.1128/AAC.01433-102 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Zeitlinger, Markus A.4 aut
2451 0a Protein Binding :b Do We Ever Learn?
264 1c 2011
338 a print2 rdacarrier
520 a Although the influence of protein binding (PB) on antibacterial activity has been reported for many antibiotics and over many years, there is currently no standardization for pharmacodynamic models that account for the impact of protein binding of antimicrobial agents in vitro. This might explain the somewhat contradictory results obtained from different studies. Simple in vitro models which compare the MIC obtained in protein-free standard medium versus a protein-rich medium are prone to methodological pitfalls and may lead to flawed conclusions. Within in vitro test systems, a range of test conditions, including source of protein, concentration of the tested antibiotic, temperature, pH, electrolytes, and supplements may influence the impact of protein binding. As new antibiotics with a high degree of protein binding are in clinical development, attention and action directed toward the optimization and standardization of testing the impact of protein binding on the activity of antibiotics in vitro become even more urgent. In addition, the quantitative relationship between the effects of protein binding in vitro and in vivo needs to be established, since the physiological conditions differ. General recommendations for testing the impact of protein binding in vitro are suggested.
653 a MEDICINE
653 a MEDICIN
7001 a Derendorf, Hartmut4 aut
7001 a Mouton, Johan W.4 aut
7001 a Cars, Ottou Uppsala universitet,Infektionssjukdomar4 aut0 (Swepub:uu)ottocars
7001 a Craig, William A.4 aut
7001 a Andes, David4 aut
7001 a Theuretzbacher, Ursula4 aut
7102 a Uppsala universitetb Infektionssjukdomar4 org
7730 t Antimicrobial Agents and Chemotherapyg 55:7, s. 3067-3074q 55:7<3067-3074x 0066-4804x 1098-6596
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156025
8564 8u https://doi.org/10.1128/AAC.01433-10

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