Search: id:"swepub:oai:lup.lub.lu.se:5d0ea331-9f51-41ad-be68-503bab0cfd30" >
The influence of is...
The influence of ischemia and reperfusion time on outcome in heart transplantation
-
- Jernryd, Victoria (author)
- Lund University,Lunds universitet,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Skåne University Hospital
-
- Metzsch, Carsten (author)
- Lund University,Lunds universitet,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Skonsammare hjärtkirurgi,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Less invasive cardiac surgery,Skåne University Hospital
-
- Andersson, Bodil (author)
- Lund University,Lunds universitet,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups,Skåne University Hospital
-
show more...
-
- Nilsson, Johan (author)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Artificiell intelligens och bioinformatik inom thoraxkirurgisk vetenskap,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups,Artificial Intelligence in CardioThoracic Sciences (AICTS),Artificial Intelligence and Bioinformatics in Cardiothoracic Sciences (AIBCTS),Skåne University Hospital
-
show less...
-
(creator_code:org_t)
- 2020-03-13
- 2020
- English.
-
In: Clinical Transplantation. - : Wiley. - 0902-0063 .- 1399-0012. ; 34:5
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://onlinelibrar...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Ischemia/reperfusion may lead to graft dysfunction in heart transplantation (HT). The purpose of this study was to evaluate the influence of ischemic and reperfusion time on acute cellular rejection (ACR) within the first-year post-HT and on long-term outcomes. Data were collected from 331 patients (mean age 49 ± 12 y, 28% females) who underwent HT 1988-2016. Endomyocardial biopsies obtained within the first year after HT were graded according to the 2004-ISHLT-WF. We classified the patients by ischemic time 4 hours, and of these, 31 (55%) patients had reperfusion with CPB ≥90 minutes. Ischemia >4 hours had an increased risk of ACR ≥ 2R during the first year (adjusted OR = 3.1, P =.016); however, an extended reperfusion ≥90 minutes reduced the risk (adjusted OR = 0.25, P =.024). The conditional probability of surviving 10 years post-transplant, given that the patients already survived first year, was inferior for recipients with ischemia ≥ 4 hours and reperfusion <90 minutes, 59%, compared with the other groups 83%, P =.016. Prolonged reperfusion appears to reduce the risk for ACR ≥ 2R and improve long-term survival.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- acute cellular rejection
- heart transplantation
- ischemic time
- reperfusion
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database