The impact of amyloid burden and APOE on rates of cognitive impairment in late life depression

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The impact of amyloid burden and APOE on rates of cognitive impairment in late life depression

Rhodes, Emma (author): San Francisco Veterans Administration Medical Center

Insel, Philip S. (author): Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University of California, San Francisco

Butters, Meryl A. (author): University of Pittsburgh

Morin, Ruth (author): San Francisco Veterans Administration Medical Center

Bickford, David (author): University of California, San Francisco

Tosun, Duygu (author): University of California, San Francisco,San Francisco Veterans Administration Medical Center

Gessert, Devon (author): University of Southern California

Rosen, Howie J. (author): University of California, San Francisco

Aisen, Paul (author): University of Southern California

Raman, Rema (author): University of Southern California

Landau, Susan (author): University of California, Berkeley

Saykin, Andrew (author): Indiana University

Toga, Arthur (author): University of Southern California

Jack, Clifford R. (author): Mayo Clinic Minnesota

Weiner, Michael W. (author): University of California, San Francisco,San Francisco Veterans Administration Medical Center

Nelson, Craig (author): University of California, San Francisco

MacKin, R. Scott (author): University of California, San Francisco,University of Pittsburgh

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(creator_code:org_t)

2021
2021
English 12 s.
In: Journal of Alzheimer's Disease. - 1387-2877. ; 80:3, s. 991-1002

Related links:: http://dx.doi.org/10...; show more...; https://lup.lub.lu.s...; https://doi.org/10.3...; show less...

Journal article (peer-reviewed)

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Background: Cognitive impairment (CI) is a key feature of late life depression (LLD), but the contribution of underlying neurodegenerative pathology remains unclear. Objective: To evaluate cognitive dysfunction in LLD relative to a sample of nondepressed (ND) older adults with matched levels of memory impairment and amyloid-β (Aβ) burden. Methods: Participants included 120 LLD and 240 ND older adults matched on age, education, sex, Mini-Mental State Exam, mild cognitive impairment diagnosis, and PET Aβ burden. Results: LLD showed higher rates of impairment relative to ND with 54.6% of the LLD sample demonstrating impairment in at least one cognitive domain compared to 42.9% of controls (H = 7.13, p = 0.008). LLD had poorer performance and higher rates of impairment on Rey Auditory Verbal Learning Test learning and memory compared to controls. In the overall sample, Aβ positivity was associated with worse performance on Logical Memory I (p = 0.044), Logical Memory II (p = 0.011), and Trail Making Test -B (p = 0.032), and APOE ϵ4 genotype was associated with worse performance on Logical Memory I (p =0.022); these relationships did not differ between LLD and ND. Conclusion: LLD showed higher rates of CI driven by focal deficits in verbal learning and memory. Alzheimer's disease (AD) biomarkers were associated with worse performance on timed set-shifting and story learning and memory, and these relationships were not impacted by depression status. These findings suggest that AD may account for a portion of previously reported multi-domain CI in LLD and highlight the potential for AD to confound studies of cognition in LLD.

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By the author/editor: Rhodes, Emma; Insel, Philip S.; Butters, Meryl A ...; Morin, Ruth; Bickford, David; Tosun, Duygu; show more...; Gessert, Devon; Rosen, Howie J.; Aisen, Paul; Raman, Rema; Landau, Susan; Saykin, Andrew; Toga, Arthur; Jack, Clifford R ...; Weiner, Michael ...; Nelson, Craig; MacKin, R. Scott; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Journal of Alzhe ...

By the university: Lund University

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The impact of amyloid burden and APOE on rates of cognitive impairment in late life depression

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