onr:"swepub:oai:lup.lub.lu.se:62ecbdef-36c7-448e-b8ab-809c41705eee"
Sökning: onr:"swepub:oai:lup.lub.lu.se:62ecbdef-36c7-448e-b8ab-809c41705eee" > Locus Coeruleus Deg...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03662naa a2200409 4500 | |
| 001 | oai:lup.lub.lu.se:62ecbdef-36c7-448e-b8ab-809c41705eee | |
| 003 | SwePub | |
| 008 | 221230s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/62ecbdef-36c7-448e-b8ab-809c41705eee2 URI |
| 024 | 7 | a https://doi.org/10.3233/JAD-2202762 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Matti, Nathalieu Lund University4 aut |
| 245 | 1 0 | a Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes |
| 264 | 1 | c 2022 |
| 300 | a 9 s. | |
| 520 | a Background: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. Objective: The aim of this study was to investigate the LC in FTLD subgroups. Methods: Neuropathological cases diagnosed with FTLD were included. The subgroups consisted of FTLD with tau, transactive response DNA-binding protein 43 (TDP) and fused in sarcoma (FUS). Micro-and macroscopical degeneration of the LC were assessed with respect to the number of neurons and the degree of depigmentation. A group of cognitively healthy subjects and a group with vascular cognitive impairment (VCI) served as comparison groups. Results: A total of 85 FTLD cases were included, of which 44 had FTLD-TDP, 38 had FTLD-tau, and three had FTLD-FUS. The groups were compared with 25 VCI cases and 41 cognitively healthy control cases (N = 151 for the entire study). All FTLD groups had a statistically higher microscopical degeneration of the LC compared to the controls, but the FTLD-tau group had greater micro-and macroscopical degeneration than the FTLD-TDP group. Age correlated positively with the LC score in the FTLD-tau group, but not in the FTLD-TDP group. Conclusion: A greater microscopical degeneration of the LC was observed in all FTLD cases compared to healthy controls and those with VCI. The LC degeneration was more severe in FTLD-tau than in FTLD-TDP. The macroscopically differential degeneration of the LC in FTLD subgroups may facilitate differential diagnostics, potentially with imaging. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Frontotemporal dementia | |
| 653 | a locus coeruleus | |
| 653 | a neuronal counts | |
| 653 | a tau | |
| 653 | a tauopathy | |
| 653 | a TDP-43 | |
| 700 | 1 | a Javanshiri, Keivanu Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ke2212ja |
| 700 | 1 | a Haglund, Mattiasu Lund University4 aut0 (Swepub:lu)pat-mh0 |
| 700 | 1 | a Saenz-Sardá, Xavieru Lund University4 aut |
| 700 | 1 | a Englund, Elisabetu Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-een |
| 710 | 2 | a Lund Universityb Patologi, Lund4 org |
| 773 | 0 | t Journal of Alzheimer's Diseaseg 89:2, s. 463-471q 89:2<463-471x 1387-2877 |
| 856 | 4 | u http://dx.doi.org/10.3233/JAD-220276x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/62ecbdef-36c7-448e-b8ab-809c41705eee |
| 856 | 4 8 | u https://doi.org/10.3233/JAD-220276 |
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