Decreased monoamine metabolites in frontotemporal dementia and Alzheimer's disease

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Fältnamn	Indikatorer	Metadata
000		03014naa a2200325 4500
001		oai:lup.lub.lu.se:79195e88-189b-4bd4-a315-0cdc2e24c7b0
003		SwePub
008		160401s1998 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/12965472 URI
024	7	a https://doi.org/10.1016/S0197-4580(98)00086-42 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Sjogren, M4 aut
245	1 0	a Decreased monoamine metabolites in frontotemporal dementia and Alzheimer's disease
264	1	c 1998
520		a The concentrations of the monoamine metabolites homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (HMPG) in the cerebrospinal fluid (CSF) of patients with clinical frontotemporal dementia (FTD; n = 30), early onset Alzheimer's disease (EAD; n = 33), late onset Alzheimer's disease (LAD, n = 27) and normal controls (n = 31) were determined using HPLC. ANCOVA showed no significant effect of neuroleptic medication, extrapyramidal signs, myoclonia or gender on the CSF levels of the monoamine metabolites. Homovanillic acid was significantly reduced in all diagnostic groups (FTD, p = 0.0002; EAD, p = 0.016; LAD, p = 0.013). 5-Hydroxyindoleacetic acid was significantly reduced in EAD (p = 0.013) and in LAD (p = 0.0014), and HMPG was reduced in LAD only (p = 0.020). HMPG was significantly higher in FTD compared to EAD (p = 0.0005) and LAD (p = 0.0003). CSF-5-HIAA was significantly reduced in patients with antidepressant medication (p = 0.006). ANCOVA within the FTD group showed no significant effect of neuroleptic or antidepressant medication, extrapyramidal signs, myoclonia, gender or FTD subtype on the CSF levels of the monoamine metabolites. The results suggest that CSF-HMPG might differentiate FTD from EAD and LAD, but not from normals.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng
700	1	a Minthon, Lennartu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)psyk-lmi
700	1	a Passant, Ullau Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)psyk-upa
700	1	a Blennow, K4 aut
700	1	a Wallin, A4 aut
710	2	a Klinisk minnesforskningb Forskargrupper vid Lunds universitet4 org
773	0	t Neurobiology of Agingg 19:5, s. 379-384q 19:5<379-384x 1558-1497
856	4	u http://dx.doi.org/10.1016/S0197-4580(98)00086-4y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/1296547
856	4 8	u https://doi.org/10.1016/S0197-4580(98)00086-4

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By the author/editor: Sjogren, M; Minthon, Lennart; Passant, Ulla; Blennow, K; Wallin, A

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Geriatrics

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