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Primary metastatic Ewing's family tumors: results of the Italian Sarcoma Group and Scandinavian Sarcoma Group ISG/SSG IV Study including myeloablative chemotherapy and total-lung irradiation
- Luksch, R. (author)
- Tienghi, A. (author)
- Hall, K. Sundby (author)
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- Fagioli, F. (author)
- Picci, P. (author)
- Barbieri, E. (author)
- Gandola, L. (author)
- Ruggieri, P. (author)
- Daolio, P. (author)
- Lindholm, P. (author)
- Prete, A. (author)
- Bisogno, G. (author)
- Tamburini, A. (author)
- Grignani, G. (author)
- Abate, M. E. (author)
- Podda, M. (author)
- Smeland, S. (author)
- Ferrari, S. (author)
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- (creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
- In: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 23:11, s. 2970-2976
- Journal article (peer-reviewed)
Abstract
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- The Italian Sarcoma Group and the Scandinavian Sarcoma Group designed a joint study to improve the prognosis for patients with Ewing's family tumors and synchronous metastatic disease limited to the lungs, or the pleura, or a single bone. The study was opened in 1999 and closed to the enrollment in 2008. The program consisted of intensive five-drug combination chemotherapy, surgery and/or radiotherapy as local treatment, and consolidation treatment with high-dose busulfan/melphalan plus autologous stem cell rescue and total-lung irradiation. During the study period, 102 consecutive patients were enrolled. The median follow-up was 62 months (range 24-124). The 5-year event-free survival probability was 0.43 [standard deviation (SD) = 0.05] and the 5-year overall survival probability was 0.52 (SD = 0.052). Unfavorable prognostic factors emerging on multivariate analysis were a poor histological/radiological response at the site of the primary tumor [relative risk (RR) = 3.4], and incomplete radiological remission of lung metastases after primary chemotherapy (RR = 2.6). One toxic death and one secondary leukemia were recorded. This intensive approach is feasible and long-term survival is achievable in similar to 50% of patients. New treatment approaches are warranted for patients responding poorly to primary chemotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Ewing's sarcoma
- high-dose chemotherapy
- lung metastases
- total-lung
- irradiation
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- art (subject category)
- ref (subject category)
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- Luksch, R.
- Tienghi, A.
- Hall, K. Sundby
- Fagioli, F.
- Picci, P.
- Barbieri, E.
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- Gandola, L.
- Eriksson, Mikael
- Ruggieri, P.
- Daolio, P.
- Lindholm, P.
- Prete, A.
- Bisogno, G.
- Tamburini, A.
- Grignani, G.
- Abate, M. E.
- Podda, M.
- Smeland, S.
- Ferrari, S.
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- MEDICAL AND HEALTH SCIENCES
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