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Children's erythroc...
Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity
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- Niinistö, Sari (author)
- Finnish National Institute for Health and Welfare
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- Erlund, Iris (author)
- Finnish National Institute for Health and Welfare
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- Lee, Hye-Seung (author)
- University of South Florida
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- Uusitalo, Ulla (author)
- University of South Florida
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- Salminen, Irma (author)
- Finnish National Institute for Health and Welfare
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- Aronsson, Carin Andrén (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Parikh, Hemang M (author)
- University of South Florida
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- Liu, Xiang (author)
- University of South Florida
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- Hummel, Sandra (author)
- Technical University of Munich
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- Toppari, Jorma (author)
- University of Turku
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- She, Jin-Xiong (author)
- University of South Florida
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Ziegler, Annette G (author)
- Technical University of Munich
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- Rewers, Marian (author)
- University of Colorado School of Medicine
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- Akolkar, Beena (author)
- National Institutes of Health, United States
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- Krischer, Jeffrey P (author)
- University of South Florida
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- Galas, David (author)
- Pacific Northwest Research Institute
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- Das, Siba (author)
- Pacific Northwest Research Institute
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- Sakhanenko, Nikita (author)
- Pacific Northwest Research Institute
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- Rich, Stephen S (author)
- University of Virginia
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- Hagopian, William (author)
- Pacific Northwest Research Institute
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- Norris, Jill M (author)
- University of Colorado-Denver
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- Virtanen, Suvi M (author)
- Finnish National Institute for Health and Welfare
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(creator_code:org_t)
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- 2021-02-11
- 2021
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
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Abstract
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- Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case-control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n - 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n - 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Niinistö, Sari
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Erlund, Iris
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Lee, Hye-Seung
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Uusitalo, Ulla
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Salminen, Irma
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Aronsson, Carin ...
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show more...
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Parikh, Hemang M
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Liu, Xiang
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Hummel, Sandra
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Toppari, Jorma
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She, Jin-Xiong
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Lernmark, Åke
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Ziegler, Annette ...
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Rewers, Marian
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Akolkar, Beena
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Krischer, Jeffre ...
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Galas, David
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Das, Siba
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Sakhanenko, Niki ...
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Rich, Stephen S
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Hagopian, Willia ...
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Norris, Jill M
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Virtanen, Suvi M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Scientific Repor ...
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Lund University